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Browsing Pharmaceutics by Title
Now showing items 17-36 of 80
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A Comparison, Evaluation and Accuracy Assessment of the Fluidigm (TM) Platform in Genotyping Common and Rare variants in an Alaska Native Population
(2014-04-30)<underline>A Comparison, Evaluation and Accuracy Assessment of the Fluidigm <super>(TM)</super> Platform in Genotyping Common and Rare variants in an Alaska Native Population</underline> by Joseph Yracheta Pharmacogenomics ... -
A Cost Minimization Analysis of Home versus Lab-based Diagnosis of Obstructive Sleep Apnea
(2014-04-30)Importance: Insurers have adopted new reimbursement policies for diagnosing and treating obstructive sleep apnea (OSA) using home sleep testing (HST) instead of laboratory-based strategies. Objective: We conducted an ... -
Cost-Utility Analysis of Medications for Relapsing-Remitting Multiple Sclerosis: A United States Third-Party Payer Perspective
Background: Many new disease-modifying therapies (DMTs) have recently been approved for relapsing-remitting multiple sclerosis (RRMS) in the United States. Objective: To assess the values of 10 first-line therapies for ... -
Determining the Effect of Isotretinoin on CYP2D6 and CYP3A4 Activity in Patients with Severe Acne
Cytochrome P450 2D6 (CYP2D6) and 3A4 (CYP3A4) are critical enzymes involved in the metabolism of commonly used drugs. There are high inter-individual variabilities in CYP2D6 drug-metabolizing activities, majorly caused by ... -
Development of a Cystic Fibrosis Microphysiological Model of the Kidney Proximal Tubule
Abstract: Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by a spectrum of mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), whose protein product functions as a chloride ... -
Development of a Microphysiological Model of the Kidney Proximal Tubule and Application in Predictive Toxicity Testing of Polymyxin Antibiotics
Late-stage attrition of investigational new drugs can be extremely devastating to both the drug developer as well as the patient in regard to money lost and disease left untreated, respectively. A primary reason for a ... -
Development of Long-acting Formulation of Dolutegravir Sodium for Human Immunodeficiency Virus
Human immunodeficiency virus (HIV) is an enveloped retrovirus that attacks the infected human host’s immune system by destroying CD4 lymphocytes, the cells responsible for providing protection against infections and ... -
Development of Microphysiological Models for the Assessment of Xenobiotic and Endobiotic Absorption and Disposition
Animal models and in vitro systems have long been relied upon to provide insights into the toxicology, pharmacodynamics and pharmacokinetics of investigational drug candidates before they are administered to human subjects. ... -
Discovery and Assessment of Endogenous Biomarkers of CYP2D6 Activity for Application in Clinical Studies
The activity of cytochrome P450 2D6 (CYP2D6) is highly variable due to genetic and environmental influences. Assessing CYP2D6 activity may aid in initial dosing of drugs metabolized by CYP2D6, help maximize therapeutic ... -
Drug Disposition during Pregnancy: Transport, Metabolism, and the Gut Microbiome
Medication use during pregnancy is increasingly prevalent and medically necessary to maintain maternal health. Yet, a quarter of medications used by pregnant women have unknown safety for the pregnant population. It is ... -
Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines
Proinflammatory cytokines, elevated during inflammation caused by infection and/or autoimmune disorders, result in reduced clearance of drugs eliminated primarily by cytochrome P450 enzymes (CYPs). However, the effect of ... -
The economic and clinical outcomes and policy implications of gene expression profiling in breast cancer care
(2004)In the U.S., the majority of premenopausal breast cancer patients are recommended by clinical guidelines to receive adjuvant chemotherapy to prevent disease progression and increase survival. However, low-risk patients may ... -
Elucidating Mechanisms for Drug Combination Nanoparticles to Enhance and Prolong Lymphatic Exposure: Experimental and Modeling Approaches
Human immunodeficiency virus (HIV) infection and metastatic cancers impact over 50 million people worldwide. Because HIV and metastatic cancers exploit the lymphatics to persist and spread, enhanced and prolonged lymphatic ... -
Endogenous Biomarkers of CYP3A Activity
(2013-07-25)The activity of the drug-metabolizing enzyme cytochromes P450 3A (CYP3A) varies up to 20-fold between individuals. The interindividual variability may be due to both genetic variations and factors such as age, diet, ... -
Enhancement of gemcitabine and paclitaxel uptake and retention in metastatic cancer cells: A novel targeted combination delivery approach to eliminate breast cancer in blood and lymph
The best current breast cancer treatments are limited by a lifelong concern for tumor recurrence. The inability of therapies to eliminate residual cancer cells after surgery leads to disease progression and metastasis. ... -
Evaluating the Impact of Microgravity on a Microphysiologic Model of Kidney Stone Disease
The kidney is a key organ for filtering of waste products as well as elimination of drugs and their metabolites. The kidney also plays an important role in mediating calcium homeostasis and bone mineralization by through ... -
Evaluation and Potential Cost-Effectiveness of Active Surveillance Pharmacovigilance for First-Line HAART in Namibia
Background. Active surveillance pharmacovigilance (PV) is a systematic approach to medicine safety assessment and health systems strengthening. These systems can better estimate the burden of adverse events (AEs) and can ... -
Evaluation of a Prescription Drug Pay-for-Performance Program: Impact on Prescribing Trends, Budget, and Patient Outcomes
Background Health plans have incentivized providers for patient care that follows evidence-based prescribing, including through pay-for-performance (P4P) programs. Research has suggested increased cost-sharing for prescription ... -
Function and Regulation of Cytochrome P450 4V2 and the Implications in Bietti’s Crystalline Dystrophy
Background: Cytochrome P450 4V2 (CYP4V2) is one of 57 functional human isozymes in the cytochrome P450 superfamily of heme-containing monooxygenase enzymes. CYP4V2 is one of thirteen human P450 enzymes classified as ‘orphans’ ...