Browsing Pharmaceutics by Author "Wang, Joanne"
Now showing items 1-6 of 6
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Molecular Mechanisms of Drug Transport at the Blood-CSF Barrier Revealed by Live Tissue Imaging and Quantitative Fluorescence Microscopy
Sun, AustinThe blood-cerebrospinal fluid barrier (BCSFB) is formed by the choroid plexus epithelial (CPE) cells, which express several polyspecific membrane transporters that contribute towards clearance of xenobiotic and endogenous ... -
Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
YIN, JIADrug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the ... -
The Role of Organic Cation Transporter 3 in Metformin Disposition during Pregnancy
Lee, Nora (2014-02-24)Metformin, a front line drug for type 2 diabetes mellitus, has been recently introduced as an alternative therapy for insulin in treatment of gestational diabetes mellitus. Despite clinical enthusiasm for the drug, there ... -
The Polyspecific Organic Cation Transporters: Role in Cancer Drug Targeting, Xenobiotic Disposition, and Drug-drug Interactions
Salvador Vieira, LeticiaThe polyspecific organic cation transporters (pOCTs) include the organic cation transporters (OCT1-3), the multidrug and toxin extrusion proteins (MATE1/2K) and the plasma membrane monoamine transporter (PMAT). These ... -
The Role of Organic Cation Transporters in the Disposition, Drug-Drug Interactions, and Tissue Toxicity of Amphetamines
Wagner, David JamesThis dissertation research aims to elucidate the roles of organic cation transporters in the disposition, drug-drug interactions, and toxicity of methamphetamine. Work conducted in this dissertation research has elucidated ... -
The Roles of the Polyspecific Organic Cation Transporters in the Disposition of meta-Iodobenzylguanidine and Implications for Toxicities and Drug Interactions
López Quiñones, Antonio Jesúsmeta-Iodobenzylguanidine (mIBG) is a radiopharmaceutical used as diagnostic agent and a targeted radiotherapy for neuroendocrine cancers. 131I-mIBG enters the cancer cells through the human norepinephrine transporter (hNET) ...