Browsing Pharmaceutics by Issue Date
Now showing items 1-20 of 80
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The role of drug-lipid interactions in biodistribution and therapeutic effects for drugs incorporated into liposomes
(1999)While a number of drugs formulated in liposomes or lipid vesicles are approved for human use, many are formulated empirically, without a full or complete understanding the role of drug-lipid interactions. Hence, the primary ... -
Metabolic and inhibitory differences between cytochromes P450 3A4 and 3A5
(2001)Cytochrome P450 (CYP) 3A4 and 3A5 constitute the dominant drug metabolizing enzymes in the liver and small intestine, and the content and activity of these enzymes is widely variable. Accurate knowledge of in vivo CYP3A ... -
Blood safety and resource allocation: economic analyses of donated blood safety initiatives
(2003)Risk management at any cost has become the apparent policy of blood banks and regulators because of transfusion-transmitted HIV and hepatitis. However, blood bank opinion leaders suggest economic analyses of new interventions ... -
The economic and clinical outcomes and policy implications of gene expression profiling in breast cancer care
(2004)In the U.S., the majority of premenopausal breast cancer patients are recommended by clinical guidelines to receive adjuvant chemotherapy to prevent disease progression and increase survival. However, low-risk patients may ... -
Investigating the Association Between Sedative Hypnotic Prescription Exposures and Motor Vehicle Crashes
(2012-09-13)Background Motor vehicle crashes occur daily and may be fatal for the driver, passengers or bystanders. Crashes have been shown to be associated with certain medical conditions and exposure to prescription medications that ... -
Migraine-specific health resource utilization in chronic and episodic migraine across six countries
(2012-09-13)Background: Though studies have consistently revealed variation in resource utilization between chronic and episodic migraineurs, less is known about how these differences compare across countries. This research describes ... -
The impact of adherence and an intervention program on patient outcomes and costs in chronic hepatitis C infection
(2012-09-13)<bold>Background and aims:</bold> Both observational studies and randomized trials have shown that higher medication adherence is associated with improved outcomes in patients with chronic hepatitis C infection (CHC). ... -
Screening for MicroRNA Regulators of an Orphan Cytochrome P450 4V2 (CYP4V2)
(2012-09-13)Cytochrome P450 4V2 (CYP4V2) is a gene linked to the ocular disease Bietti's Crystalline Dystrophy (BCD). Sequence analysis of CYP4V2 in BCD patients identified potentially disruptive exonic and intronic mutations. Patients ... -
Adverse Events Associated with Bevacizumab and Chemotherapy in Older Patients with Metastatic Colorectal Cancer
(2012-09-13)<bold>Background</bold>: The safety of bevacizumab in older metastatic colorectal cancer (mCRC) patients is not well understood. The purpose of this analysis was to determine the prevalence of treatment–associated adverse ... -
The Impact of CYP3A5 Variation and Pregnancy on the Metabolic Disposition of Calcineurin Inhibitors
(2013-02-25)The calcineurin inhibitors (CNI) — cyclosporine A (CsA) and tacrolimus remain the backbone of immunosuppression therapy for most organ transplant patients despite their serious side effects, such as chronic calcineurin ... -
Transporter and Metabolic-based Drug-Drug Interactions: The Blood-Brain Barrier and The Liver
(2013-04-17)The HIV Protease inhibitor (PI)-based DDIs are complex, unpredictable and often paradoxical. Investigations dedicated to evaluating PIs' potential as inducers of the CYPs and drug transporter, and PIs' as substrates of ... -
Predicting Drug Disposition during Pregnancy through Modeling and Simulation
(2013-07-23)Physiological and ADME changes during pregnancy can significantly affect drug pharmacokinetics and may necessitate dose adjustment. Since it is logistically impossible to delineate the changes in PK of all drugs administered ... -
Prediction of in vivo metabolite disposition and complex metabolite-dependent drug-drug interactions
(2013-07-25)Metabolites can have pharmacological or toxicological effects, inhibit metabolic enzymes and be used as probes of drug-drug interactions or specific cytochrome P450 phenotypes. Thus better understanding and prediction ... -
The Relative Importance of CYP26A1 and CYP26B1 in Mediating Retinoid Homeostasis: Studies on the Formation, Elimination and Biological Activity of All-trans-Retinoic Acid Metabolites
(2013-07-25)All-trans-retinoic acid (atRA), the active metabolite of Vitamin A (retinol), is an essential nutrient during both fetal development and adult life. The concentration of atRA within a cell is tightly regulated by the ... -
Endogenous Biomarkers of CYP3A Activity
(2013-07-25)The activity of the drug-metabolizing enzyme cytochromes P450 3A (CYP3A) varies up to 20-fold between individuals. The interindividual variability may be due to both genetic variations and factors such as age, diet, ... -
The Role of Organic Cation Transporter 3 in Metformin Disposition during Pregnancy
(2014-02-24)Metformin, a front line drug for type 2 diabetes mellitus, has been recently introduced as an alternative therapy for insulin in treatment of gestational diabetes mellitus. Despite clinical enthusiasm for the drug, there ... -
The Impact of R10-Hydroxywarfarin on CYP2C9-Mediated S-Warfarin Metabolism
(2014-04-30)Warfarin therapy is highly effective in treating both atrial fibrillation and deep vein thrombosis. Currently, more than 20 million Americans are receiving warfarin therapy. However, increased risk of adverse events are ...