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Browsing Pharmaceutics by Subject "Pharmacology"
Now showing items 1-4 of 4
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Predicting Human Fetal Drug Exposure to Placental P-glycoprotein Substrates by PBPK Modeling and Simulation
More than 80% of pregnant women take at least one drug during pregnancy and about 50% during the first trimester when the fetus is the most vulnerable to drug toxicity (Scaffidi, Mol, & Keelan, 2017). To inform fetal risk ... -
Prediction of in vivo metabolite disposition and complex metabolite-dependent drug-drug interactions
(2013-07-25)Metabolites can have pharmacological or toxicological effects, inhibit metabolic enzymes and be used as probes of drug-drug interactions or specific cytochrome P450 phenotypes. Thus better understanding and prediction ... -
Quantification and Prediction of Human Fetal (-)-Δ9-tetrahydrocannabinol (THC)/11-OH-THC Exposure to Inform Neurodevelopmental Toxicity of Cannabis
Prenatal cannabis use is associated with various detrimental outcomes in the offspring, the foremost being neurodevelopmental toxicity1-5. Δ9-tetrahydrocannabinol (THC) is the most abundant psychoactive compound in cannabis ... -
Transporter and Metabolic-based Drug-Drug Interactions: The Blood-Brain Barrier and The Liver
(2013-04-17)The HIV Protease inhibitor (PI)-based DDIs are complex, unpredictable and often paradoxical. Investigations dedicated to evaluating PIs' potential as inducers of the CYPs and drug transporter, and PIs' as substrates of ...