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ALDH1A enzymes regulate retinoic acid homeostasis in a tissue specific manner: A model of how novel methods can unravel old unanswered questions
Retinoic acid (RA), the active form of vitamin A, is an essential signaling molecule in many tissues and the concentrations of RA are spatiotemporally controlled in target tissues. However, the source of RA in each tissue is not clear and the role of specific enzymes in RA synthesis and metabolism has not been described. While ...