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Investigating the role of drug transporters in furosemide absorption, food-effect and elimination by a proteomics informed-mechanistic PBPK modeling approach
Furosemide is a widely used diuretic for treating excessive fluid accumulation caused by disease conditions like heart failure and liver cirrhosis. Furosemide exhibits variable pharmacokinetics (PK) with bioavailability ranging from 10-100%, which is attributed to its low solubility and low permeability. Furosemide also shows ...