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Metabolic and inhibitory differences between cytochromes P450 3A4 and 3A5
Cytochrome P450 (CYP) 3A4 and 3A5 constitute the dominant drug metabolizing enzymes in the liver and small intestine, and the content and activity of these enzymes is widely variable. Accurate knowledge of in vivo CYP3A activity is vital to predicting potential drug-drug interactions that may occur. Furthermore, any inhibitory ...