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The Impact of CYP3A5 Variation and Pregnancy on the Metabolic Disposition of Calcineurin Inhibitors
(2013-02-25)
The calcineurin inhibitors (CNI) — cyclosporine A (CsA) and tacrolimus remain the backbone of immunosuppression therapy for most organ transplant patients despite their serious side effects, such as chronic calcineurin inhibitor nephrotoxicity (CNIT). CNIs are substrates for CYP3As and P-glycoprotein. Genetic and environmental ...