Browsing Pharmacology by Title
Now showing items 30-45 of 45
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Regulation of SLIT-Robo Signaling by Scaffolding Proteins
Axon guidance receptors in the growth cone respond to secreted molecular cues, directing axons towards their appropriate targets of innervation. Many of these receptors complex with scaffolding proteins which recruit protein ... -
Regulation of two subfamilies of adenylyl cyclase by Gi-coupled receptors: a possible role during cAMP-dependent synaptic plasticity in the Hippocampus
(1997)Adenylyl cyclases catalyze the synthesis of cAMP from ATP. Coupling of intracellular Ca$\sp{2+}$ to cAMP increases may be important for some forms of synaptic plasticity. The type 1 adenylyl cyclase (AC1) is a neural ... -
Resolving mechanisms of apoptosis in response to WNT3A in Melanoma
(2013-04-17)Wnt/β-catenin and ERK/MAPK signaling regulate the balance of differentiation and proliferation in melanoma. Aberrant activation of ERK/MAPK signaling results from the BRAFV600E or NRASQ61X mutations in greater than 70% of ... -
Role for cell-to-cell communication in stem cell specification toward pancreatic progenitors: relevance to the design of novel therapies for diabetes.
University of Washington Abstract Role for cell-to-cell communication in stem cell specification toward pancreatic progenitors: relevance to the design of novel therapies for diabetes. Wendy Yang Chair of the Supervisory ... -
Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
(2014-04-30)Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes ... -
Role of phosphorylation of the alpha one subunit in cyclic adenosine monophosphate dependent modulation of skeletal muscle calcium channels
(1998)Phosphorylation of the skeletal muscle $\alpha\sb1$ subunit of the L-type calcium channel has been proposed to regulate the calcium current, allowing increased calcium flux during tetanus and during $\beta$-adrenergic ... -
The roles of the high affinity cAMP-specific phosphodiesterase 8B in adrenal steroidogenesis, anxiety, and learning
(2011-03-18)The functions of the phosphodiesterase 8 family of cyclic nucleotide phosphodiesterases (PDEs) have been largely unexplored, primarily due to the lack of selective pharmacological inhibitors. The main function of PDEs is ... -
Structural and biochemical analysis of cullin-based ubiquitin ligases reveal regulatory mechanisms of ubiquitination machinery
(2006)Ubiquitin-dependent proteolysis controls protein stability and plays an important regulatory role in a broad spectrum of biological processes. At the core of the ubiquitination process are the ubiquitin ligases (UBL) that ... -
Structural basis for phosphatase regulation by the anchoring protein AKAP79
The calcium/calmodulin-activated protein phosphatase 2B (PP2B, or calcineurin) regulates diverse biological processes including glucose homeostasis and synaptic plasticity. PP2B is targeted to specific substrates, such as ... -
Structure and Function of the Mammalian Circadian Clock
Circadian clocks are essential in all kingdoms of life to maintain appropriate synchronization with their environment. Robust, 24-hr rhythms in eukaryotes are generated by a transcription-translation negative feedback loop. ... -
Structure study of a plant dual-affinity transceptor, CHL1
(2014-02-24)Nitrate is a key nutrient and signaling molecule for plant development and growth. It is the main source of inorganic nitrogen for plants grown in the aerobic soil condition. The growth of many species, including cultivated ... -
Targeted disruption of the RI and RII regulatory subunits of the cAMP-dependent protein kinase (PKA) in mice: physiological and neurobiological defects
(1996)The cAMP-dependent protein kinase (PKA) mediates the intracellular responses to myriad extracellular signals in eukaryotic organisms. Although the functions of this enzyme have been extensively studied, little is known ... -
Threshold dependence of central amygdala CRF in fear behaviors
The central nucleus of the amygdala (CeA) is critical for threat association and defensive behavior. Distinct populations of neurons in the CeA are known to express an array of neuropeptides, but the role of these different ... -
Transcriptional regulation of Atp2b2 determines the severity of AHL in C57BL/6J Mice
University of Washington Abstract Transcriptional regulation of Atp2b2 determines the severity of AHL in C57BL/6J Mice Rebecca R. Minich Chair of the Supervisory Committee: Professor Bruce L Tempel Otolaryngology-Head and ... -
Wnt/β-catenin Signaling Regulates Regeneration in Diverse Tissues of the Zebrafish
The ability to regenerate tissue after injury is limited by species, tissue type, and age of the organism. Understanding the mechanisms of endogenous regeneration provides greater insight into this remarkable biological ... -
WTX is a novel regulator of ubiquitination in the Wnt/beta-catenin and KEAP1/NRF2 pathways
(2012-08-10)Ubiquitination of proteins and subsequent proteosome-mediated degradation is one mechanism cells use to regulate protein steady-state levels. This essential process permits cells to rapidly respond to extracellular cues ...