Browsing Pharmacology by Title
Now showing items 22-41 of 82
-
Effects of GLT-1 loss on central nervous system insulin signaling and implications for Alzheimer’s disease pathogenesis
Regulation of glutamatergic neurotransmission in the central nervous system (CNS) by glutamate transporters allows for the fine balance between tightly regulated signaling and prevention of glutamate-induced neurotoxicity. ... -
Elucidating Levetiracetam action at the presynaptic terminal
Levetiracetam (KeppraTM, LEV) is the first of a growing class of anti-epileptic drugs that shows great promise in the treatment of multiple neurological disorders. LEV has a unique receptor, Synaptic Vesicle Protein 2A ... -
Elucidating the Molecular Architecture of the 1D-AR:PDZ-Protein Macromolecular Complex
G Protein-Coupled Receptors (GPCRs) are seven transmembrane proteins that are the targets for over 30% of all medications currently on the market. Adrenergic Receptors (ARs) are one type of GPCR that responds to the ... -
Elucidating the role of unique structural features of the α1D-adrenergic receptor: A tale of two tails
G protein-coupled receptors (GPCRs) are seven transmembrane domain proteins accounting for ~4% of the human genome, and the predicted target of ~30% FDA approved therapeutics. Often, drugs compete with endogenous ligands ... -
An Examination of Plasma Membrane Calcium ATPase 2 localization in the Medial Nucleus of the Trapezoid Body Reveals a Cell Size Gradient
An Examination of Plasma Membrane Calcium ATPase 2 localization in the Medial Nucleus of the Trapezoid Body Reveals a Cell Size Gradient Jessica H. Weatherstone Chair of Supervisory Committee: Professor Bruce L Tempel ... -
From yeast to mammals: the exploration of a conserved, intrinsically disordered deubiquitinase that regulates ribosomal RNA synthesis.
Ribosomes are a key component of cell cycle regulation and protein production. Proper control of ribosome synthesis is necessary for normal cellular functioning. Improper regulation can lead to cell death or uncontrolled ... -
HSP70 Isoforms Ssa1 and Ssa2 are Differentially Required in San1 Mediated Degradation
Misfolded proteins have the propensity to aggregate and become toxic to the cell if they accumulate. To counter this detrimental burden, the eukaryotic cell has developed a variety of protein quality control (PQC) mechanisms ... -
Hyperosmotic stress induced inclusion formation of a prionogenic transcriptional corepressor is regulated by glycerol accumulation.
Environmental stressors cause severe perturbations in homeostasis that, if left unchecked, can severely damage cells. In order to cope with a constantly changing environment, organisms have evolved complex signaling programs ... -
Identifying the Mechanisms Behind Radiation Resistance in Treatment Naïve Diffuse Intrinsic Pontine Glioma Models
Diffuse Intrinsic Pontine Glioma (DIPG) is a near universally fatal pediatric brain tumor that occurs in the pons and other midline structures. These tumors are characterized by the presence of a unique histone mutation: ... -
In vivo disruption of PKA activity through targeted mutations of the RIα regulatory subunit
(2014-02-24)The cAMP-dependent protein kinase (PKA) is expressed in all animal cells and plays a key regulatory role in many diverse physiological processes. The PKA holoenzyme is a heterotetramer that exists as a dimer of regulatory ... -
Investigating the role of a CaV2.1 - Syt7 interaction in Short-term Synaptic Facilitation
Synaptic facilitation is the enhancement of successive transmissions between neurons over timespans of less than a second. It is a form of synaptic plasticity which has long been observed, yet its molecular mechanisms ... -
Involvement of shaker-like potassium channels in control of nervous system hyperexcitability
(1996)Mutations at the Drosophila Shaker locus cause motor hyperexcitability in flies, and allowed the cloning of the first voltage-gated potassium channel gene. Subsequently, at least sixteen different related potassium channel ... -
Jasmonate Perception by Inositol-phosphate-potentiated COI1-JAZ Co-receptor
(2012-09-13)Jasmonates (JAs) are a family of plant hormones that regulate plant growth, development, and responses to stress. The F-box protein CORONATINE-INSENSITIVE 1 (COI1) mediates JA signaling by promoting hormone-dependent ... -
Mechanisms and physiological implications of mitochondrial and cellular calcium signaling
Calcium signaling is central to fields as disparate as memory formation, protein structure, and cellular migration. The five chapters of this dissertation each examine calcium signaling in a different context. First, an ... -
Mechanisms of Opioid Receptor Desensitization
Agonists targeting MOR are effective analgesics, but their clinical use is hindered by side effects, including tolerance and addiction. KOR agonists also produce analgesia, but clinical use of these compounds has remained ... -
Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
(2013-02-25)Unlike the proadaptive effects of acute stress exposure, repeated stress exposure results in maladaptive responses by mechanisms that are not completely understood. These maladaptive responses can lead to debilitating ... -
Modulation of Kir3 by lipids and tyrosine phosphorylation
(2000)Neurotransmitters, hormones and growth factors act on ion channels to modulate excitable tissue. When a ligand binds a receptor it may activate ion channels in the membrane to initiate multiple intracellular events. One ... -
Molecular interactions and signaling mechanisms of the oncogenic fusion protein DNAJ-PKAc in fibrolamellar carcinoma
The DNAJ-PKAc fusion kinase is a defining feature of the adolescent liver cancer fibrolamellar carcinoma (FLC). A single lesion on chromosome 19 generates this mutant kinase by creating a fused gene encoding the chaperone ... -
Molecular Regulation of Opioid Receptor Signaling
(2013-02-25)The varied behavioral effects of kappa opioid receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are ... -
Molecular Studies of Alpha-Scorpion Toxin Interactions with Voltage-gated Sodium Channels
(2012-09-13)Voltage-gated sodium channels are responsible for initiation and propagation of the action potential in vertebrate nerve and muscle. They are also the molecular targets for a large number of paralytic neurotoxins. ...