Browsing Pharmacology by Title
Now showing items 27-46 of 82
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From yeast to mammals: the exploration of a conserved, intrinsically disordered deubiquitinase that regulates ribosomal RNA synthesis.
Ribosomes are a key component of cell cycle regulation and protein production. Proper control of ribosome synthesis is necessary for normal cellular functioning. Improper regulation can lead to cell death or uncontrolled ... -
HSP70 Isoforms Ssa1 and Ssa2 are Differentially Required in San1 Mediated Degradation
Misfolded proteins have the propensity to aggregate and become toxic to the cell if they accumulate. To counter this detrimental burden, the eukaryotic cell has developed a variety of protein quality control (PQC) mechanisms ... -
Hyperosmotic stress induced inclusion formation of a prionogenic transcriptional corepressor is regulated by glycerol accumulation.
Environmental stressors cause severe perturbations in homeostasis that, if left unchecked, can severely damage cells. In order to cope with a constantly changing environment, organisms have evolved complex signaling programs ... -
Identifying the Mechanisms Behind Radiation Resistance in Treatment Naïve Diffuse Intrinsic Pontine Glioma Models
Diffuse Intrinsic Pontine Glioma (DIPG) is a near universally fatal pediatric brain tumor that occurs in the pons and other midline structures. These tumors are characterized by the presence of a unique histone mutation: ... -
In vivo disruption of PKA activity through targeted mutations of the RIα regulatory subunit
(2014-02-24)The cAMP-dependent protein kinase (PKA) is expressed in all animal cells and plays a key regulatory role in many diverse physiological processes. The PKA holoenzyme is a heterotetramer that exists as a dimer of regulatory ... -
Investigating the role of a CaV2.1 - Syt7 interaction in Short-term Synaptic Facilitation
Synaptic facilitation is the enhancement of successive transmissions between neurons over timespans of less than a second. It is a form of synaptic plasticity which has long been observed, yet its molecular mechanisms ... -
Involvement of shaker-like potassium channels in control of nervous system hyperexcitability
(1996)Mutations at the Drosophila Shaker locus cause motor hyperexcitability in flies, and allowed the cloning of the first voltage-gated potassium channel gene. Subsequently, at least sixteen different related potassium channel ... -
Jasmonate Perception by Inositol-phosphate-potentiated COI1-JAZ Co-receptor
(2012-09-13)Jasmonates (JAs) are a family of plant hormones that regulate plant growth, development, and responses to stress. The F-box protein CORONATINE-INSENSITIVE 1 (COI1) mediates JA signaling by promoting hormone-dependent ... -
Mechanisms and physiological implications of mitochondrial and cellular calcium signaling
Calcium signaling is central to fields as disparate as memory formation, protein structure, and cellular migration. The five chapters of this dissertation each examine calcium signaling in a different context. First, an ... -
Mechanisms of Opioid Receptor Desensitization
Agonists targeting MOR are effective analgesics, but their clinical use is hindered by side effects, including tolerance and addiction. KOR agonists also produce analgesia, but clinical use of these compounds has remained ... -
Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
(2013-02-25)Unlike the proadaptive effects of acute stress exposure, repeated stress exposure results in maladaptive responses by mechanisms that are not completely understood. These maladaptive responses can lead to debilitating ... -
Modulation of Kir3 by lipids and tyrosine phosphorylation
(2000)Neurotransmitters, hormones and growth factors act on ion channels to modulate excitable tissue. When a ligand binds a receptor it may activate ion channels in the membrane to initiate multiple intracellular events. One ... -
Molecular interactions and signaling mechanisms of the oncogenic fusion protein DNAJ-PKAc in fibrolamellar carcinoma
The DNAJ-PKAc fusion kinase is a defining feature of the adolescent liver cancer fibrolamellar carcinoma (FLC). A single lesion on chromosome 19 generates this mutant kinase by creating a fused gene encoding the chaperone ... -
Molecular Regulation of Opioid Receptor Signaling
(2013-02-25)The varied behavioral effects of kappa opioid receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are ... -
Molecular Studies of Alpha-Scorpion Toxin Interactions with Voltage-gated Sodium Channels
(2012-09-13)Voltage-gated sodium channels are responsible for initiation and propagation of the action potential in vertebrate nerve and muscle. They are also the molecular targets for a large number of paralytic neurotoxins. ... -
Novel antitubulin agents uncover new players in microtubule regulation and cell division in cancer
Glioblastoma multiforme (GBM) is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed with GBM beyond 14-15 months in part because the blood-brain ... -
Novel KOR Antidepressant and Analgesic Strategies
The broad goal of this thesis has been to gain a better understanding of the mechanisms involved in depression and pain. These disorders are highly prevalent in our society and present an extreme burden for our economy, ... -
Novel tools for multi-omic characterization of subnuclear RNA-scaffolded structures in development and disease
RNA molecules are increasingly recognized as fundamental regulators of subcellular organization. In the nucleus, RNAs scaffold numerous structures that mediate diverse and essential genomic functions. These range from ... -
On the Development of a Technique to Isolate Newly Recycled Synaptic Vesicles for the Purpose of Studying the Mechanism of Action of the Anticonvulsant Drug Levetiracetam
Levetiracetam (lev) is a clinically used anti-epileptic drug. In contrast to traditional anti-epileptic drugs that target ion channels or GABAergic neurotransmission in order to globally depress synaptic activity, lev ... -
Pharmacologic regulation of Wnt/β-Catenin Signaling in Stem and Progenitor Cells
(2014-04-30)The Wnt/Ã -Catenin signaling pathway is a key regulator of proliferation, differentiation, and programmed cell death in stem and progenitor cells. Misregulated or aberrant signaling events in the pathway contributes to the ...