Browsing Pharmacology by Title
Now showing items 35-54 of 82
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Mechanisms and physiological implications of mitochondrial and cellular calcium signaling
Calcium signaling is central to fields as disparate as memory formation, protein structure, and cellular migration. The five chapters of this dissertation each examine calcium signaling in a different context. First, an ... -
Mechanisms of Opioid Receptor Desensitization
Agonists targeting MOR are effective analgesics, but their clinical use is hindered by side effects, including tolerance and addiction. KOR agonists also produce analgesia, but clinical use of these compounds has remained ... -
Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
(2013-02-25)Unlike the proadaptive effects of acute stress exposure, repeated stress exposure results in maladaptive responses by mechanisms that are not completely understood. These maladaptive responses can lead to debilitating ... -
Modulation of Kir3 by lipids and tyrosine phosphorylation
(2000)Neurotransmitters, hormones and growth factors act on ion channels to modulate excitable tissue. When a ligand binds a receptor it may activate ion channels in the membrane to initiate multiple intracellular events. One ... -
Molecular interactions and signaling mechanisms of the oncogenic fusion protein DNAJ-PKAc in fibrolamellar carcinoma
The DNAJ-PKAc fusion kinase is a defining feature of the adolescent liver cancer fibrolamellar carcinoma (FLC). A single lesion on chromosome 19 generates this mutant kinase by creating a fused gene encoding the chaperone ... -
Molecular Regulation of Opioid Receptor Signaling
(2013-02-25)The varied behavioral effects of kappa opioid receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are ... -
Molecular Studies of Alpha-Scorpion Toxin Interactions with Voltage-gated Sodium Channels
(2012-09-13)Voltage-gated sodium channels are responsible for initiation and propagation of the action potential in vertebrate nerve and muscle. They are also the molecular targets for a large number of paralytic neurotoxins. ... -
Novel antitubulin agents uncover new players in microtubule regulation and cell division in cancer
Glioblastoma multiforme (GBM) is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed with GBM beyond 14-15 months in part because the blood-brain ... -
Novel KOR Antidepressant and Analgesic Strategies
The broad goal of this thesis has been to gain a better understanding of the mechanisms involved in depression and pain. These disorders are highly prevalent in our society and present an extreme burden for our economy, ... -
Novel tools for multi-omic characterization of subnuclear RNA-scaffolded structures in development and disease
RNA molecules are increasingly recognized as fundamental regulators of subcellular organization. In the nucleus, RNAs scaffold numerous structures that mediate diverse and essential genomic functions. These range from ... -
On the Development of a Technique to Isolate Newly Recycled Synaptic Vesicles for the Purpose of Studying the Mechanism of Action of the Anticonvulsant Drug Levetiracetam
Levetiracetam (lev) is a clinically used anti-epileptic drug. In contrast to traditional anti-epileptic drugs that target ion channels or GABAergic neurotransmission in order to globally depress synaptic activity, lev ... -
Pharmacologic regulation of Wnt/β-Catenin Signaling in Stem and Progenitor Cells
(2014-04-30)The Wnt/Ã -Catenin signaling pathway is a key regulator of proliferation, differentiation, and programmed cell death in stem and progenitor cells. Misregulated or aberrant signaling events in the pathway contributes to the ... -
Plasma Membrane Sorting of Muscarinic Acetylcholine Receptors
(2013-02-25)Cellular polarization is a process whereby a cell's structure and components are organized asymmetrically. Proper polarization is essential for cellular function in many different cell types. Immunocytochemical studies ... -
Post-transcriptional regulation of expression of the potassium channel, Kv1.1
(1998)Potassium channels (K channels) are important in setting resting membrane potentials, shaping action potentials, modulation of hormone and neurotransmitter release and regulation of neuronal firing patterns (Hille, 1992; ... -
Presynaptic Anchoring of PKA by AKAP7 is Required for Pattern Separation by Dentate Gyrus
The intracellular signaling molecule, 3',5'-cyclic adenosine monophosphate (cAMP), is produced by a cell in response to a physiological signal. A derivative of adenosine triphosphate (ATP), cAMP is produced by adenylate ... -
Regenerative Cues of Myeloid Cells on Pancreatic Epithelium
Tissue regeneration is an attractive approach to treating many degenerative diseases including diabetes mellitus, a devastating disease caused by the destruction or dysfunction of insulin-producing β cells in the pancreas. ... -
The Regulation of Brown Adipose Tissue Activation by Multiple Phosphodiesterases
(2013-07-25)Brown adipose tissue is a highly thermogenic, energy "wasting" organ that converts glucose and lipids into heat. Many of the critical metabolic and gene transcriptional processes, such as uncoupling protein-1 (UCP1) mRNA ... -
Regulation of SLIT-Robo Signaling by Scaffolding Proteins
Axon guidance receptors in the growth cone respond to secreted molecular cues, directing axons towards their appropriate targets of innervation. Many of these receptors complex with scaffolding proteins which recruit protein ... -
Regulation of two subfamilies of adenylyl cyclase by Gi-coupled receptors: a possible role during cAMP-dependent synaptic plasticity in the Hippocampus
(1997)Adenylyl cyclases catalyze the synthesis of cAMP from ATP. Coupling of intracellular Ca$\sp{2+}$ to cAMP increases may be important for some forms of synaptic plasticity. The type 1 adenylyl cyclase (AC1) is a neural ... -
Resolving mechanisms of apoptosis in response to WNT3A in Melanoma
(2013-04-17)Wnt/β-catenin and ERK/MAPK signaling regulate the balance of differentiation and proliferation in melanoma. Aberrant activation of ERK/MAPK signaling results from the BRAFV600E or NRASQ61X mutations in greater than 70% of ...