Browsing Pharmacology by Title
Now showing items 42-61 of 82
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Novel antitubulin agents uncover new players in microtubule regulation and cell division in cancer
Glioblastoma multiforme (GBM) is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed with GBM beyond 14-15 months in part because the blood-brain ... -
Novel KOR Antidepressant and Analgesic Strategies
The broad goal of this thesis has been to gain a better understanding of the mechanisms involved in depression and pain. These disorders are highly prevalent in our society and present an extreme burden for our economy, ... -
Novel tools for multi-omic characterization of subnuclear RNA-scaffolded structures in development and disease
RNA molecules are increasingly recognized as fundamental regulators of subcellular organization. In the nucleus, RNAs scaffold numerous structures that mediate diverse and essential genomic functions. These range from ... -
On the Development of a Technique to Isolate Newly Recycled Synaptic Vesicles for the Purpose of Studying the Mechanism of Action of the Anticonvulsant Drug Levetiracetam
Levetiracetam (lev) is a clinically used anti-epileptic drug. In contrast to traditional anti-epileptic drugs that target ion channels or GABAergic neurotransmission in order to globally depress synaptic activity, lev ... -
Pharmacologic regulation of Wnt/β-Catenin Signaling in Stem and Progenitor Cells
(2014-04-30)The Wnt/Ã -Catenin signaling pathway is a key regulator of proliferation, differentiation, and programmed cell death in stem and progenitor cells. Misregulated or aberrant signaling events in the pathway contributes to the ... -
Plasma Membrane Sorting of Muscarinic Acetylcholine Receptors
(2013-02-25)Cellular polarization is a process whereby a cell's structure and components are organized asymmetrically. Proper polarization is essential for cellular function in many different cell types. Immunocytochemical studies ... -
Post-transcriptional regulation of expression of the potassium channel, Kv1.1
(1998)Potassium channels (K channels) are important in setting resting membrane potentials, shaping action potentials, modulation of hormone and neurotransmitter release and regulation of neuronal firing patterns (Hille, 1992; ... -
Presynaptic Anchoring of PKA by AKAP7 is Required for Pattern Separation by Dentate Gyrus
The intracellular signaling molecule, 3',5'-cyclic adenosine monophosphate (cAMP), is produced by a cell in response to a physiological signal. A derivative of adenosine triphosphate (ATP), cAMP is produced by adenylate ... -
Regenerative Cues of Myeloid Cells on Pancreatic Epithelium
Tissue regeneration is an attractive approach to treating many degenerative diseases including diabetes mellitus, a devastating disease caused by the destruction or dysfunction of insulin-producing β cells in the pancreas. ... -
The Regulation of Brown Adipose Tissue Activation by Multiple Phosphodiesterases
(2013-07-25)Brown adipose tissue is a highly thermogenic, energy "wasting" organ that converts glucose and lipids into heat. Many of the critical metabolic and gene transcriptional processes, such as uncoupling protein-1 (UCP1) mRNA ... -
Regulation of SLIT-Robo Signaling by Scaffolding Proteins
Axon guidance receptors in the growth cone respond to secreted molecular cues, directing axons towards their appropriate targets of innervation. Many of these receptors complex with scaffolding proteins which recruit protein ... -
Regulation of two subfamilies of adenylyl cyclase by Gi-coupled receptors: a possible role during cAMP-dependent synaptic plasticity in the Hippocampus
(1997)Adenylyl cyclases catalyze the synthesis of cAMP from ATP. Coupling of intracellular Ca$\sp{2+}$ to cAMP increases may be important for some forms of synaptic plasticity. The type 1 adenylyl cyclase (AC1) is a neural ... -
Resolving mechanisms of apoptosis in response to WNT3A in Melanoma
(2013-04-17)Wnt/β-catenin and ERK/MAPK signaling regulate the balance of differentiation and proliferation in melanoma. Aberrant activation of ERK/MAPK signaling results from the BRAFV600E or NRASQ61X mutations in greater than 70% of ... -
Role for cell-to-cell communication in stem cell specification toward pancreatic progenitors: relevance to the design of novel therapies for diabetes.
University of Washington Abstract Role for cell-to-cell communication in stem cell specification toward pancreatic progenitors: relevance to the design of novel therapies for diabetes. Wendy Yang Chair of the Supervisory ... -
Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
(2014-04-30)Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes ... -
Role of phosphorylation of the alpha one subunit in cyclic adenosine monophosphate dependent modulation of skeletal muscle calcium channels
(1998)Phosphorylation of the skeletal muscle $\alpha\sb1$ subunit of the L-type calcium channel has been proposed to regulate the calcium current, allowing increased calcium flux during tetanus and during $\beta$-adrenergic ... -
The roles of the high affinity cAMP-specific phosphodiesterase 8B in adrenal steroidogenesis, anxiety, and learning
(2011-03-18)The functions of the phosphodiesterase 8 family of cyclic nucleotide phosphodiesterases (PDEs) have been largely unexplored, primarily due to the lack of selective pharmacological inhibitors. The main function of PDEs is ... -
Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are ... -
Social Transmission of a Stress-Related Neuroadaptation
Stress is highly pervasive in humans, impacting motivated behaviors with an enormous toll on life quality. Many of the effects of stress are orchestrated by neuropeptides such as corticotropin-releasing factor (CRF). It ... -
Stimulus-Dependent Regulation of 2-Arachidonoyl Glycerol Signaling and the Mechanism of its Hydrolysis by ABHD6
Cannabis has been used for thousands of years for recreational and therapeutic effects. The efficacy of medicinal cannabis for conditions such as epilepsy and pain has resulted in the discovery of the molecular targets of ...