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Browsing Pharmacology by Title
Now showing items 50-69 of 82
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Regenerative Cues of Myeloid Cells on Pancreatic Epithelium
Tissue regeneration is an attractive approach to treating many degenerative diseases including diabetes mellitus, a devastating disease caused by the destruction or dysfunction of insulin-producing β cells in the pancreas. ... -
The Regulation of Brown Adipose Tissue Activation by Multiple Phosphodiesterases
(2013-07-25)Brown adipose tissue is a highly thermogenic, energy "wasting" organ that converts glucose and lipids into heat. Many of the critical metabolic and gene transcriptional processes, such as uncoupling protein-1 (UCP1) mRNA ... -
Regulation of SLIT-Robo Signaling by Scaffolding Proteins
Axon guidance receptors in the growth cone respond to secreted molecular cues, directing axons towards their appropriate targets of innervation. Many of these receptors complex with scaffolding proteins which recruit protein ... -
Regulation of two subfamilies of adenylyl cyclase by Gi-coupled receptors: a possible role during cAMP-dependent synaptic plasticity in the Hippocampus
(1997)Adenylyl cyclases catalyze the synthesis of cAMP from ATP. Coupling of intracellular Ca$\sp{2+}$ to cAMP increases may be important for some forms of synaptic plasticity. The type 1 adenylyl cyclase (AC1) is a neural ... -
Resolving mechanisms of apoptosis in response to WNT3A in Melanoma
(2013-04-17)Wnt/β-catenin and ERK/MAPK signaling regulate the balance of differentiation and proliferation in melanoma. Aberrant activation of ERK/MAPK signaling results from the BRAFV600E or NRASQ61X mutations in greater than 70% of ... -
Role for cell-to-cell communication in stem cell specification toward pancreatic progenitors: relevance to the design of novel therapies for diabetes.
University of Washington Abstract Role for cell-to-cell communication in stem cell specification toward pancreatic progenitors: relevance to the design of novel therapies for diabetes. Wendy Yang Chair of the Supervisory ... -
Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
(2014-04-30)Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes ... -
Role of phosphorylation of the alpha one subunit in cyclic adenosine monophosphate dependent modulation of skeletal muscle calcium channels
(1998)Phosphorylation of the skeletal muscle $\alpha\sb1$ subunit of the L-type calcium channel has been proposed to regulate the calcium current, allowing increased calcium flux during tetanus and during $\beta$-adrenergic ... -
The roles of the high affinity cAMP-specific phosphodiesterase 8B in adrenal steroidogenesis, anxiety, and learning
(2011-03-18)The functions of the phosphodiesterase 8 family of cyclic nucleotide phosphodiesterases (PDEs) have been largely unexplored, primarily due to the lack of selective pharmacological inhibitors. The main function of PDEs is ... -
Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are ... -
Social Transmission of a Stress-Related Neuroadaptation
Stress is highly pervasive in humans, impacting motivated behaviors with an enormous toll on life quality. Many of the effects of stress are orchestrated by neuropeptides such as corticotropin-releasing factor (CRF). It ... -
Stimulus-Dependent Regulation of 2-Arachidonoyl Glycerol Signaling and the Mechanism of its Hydrolysis by ABHD6
Cannabis has been used for thousands of years for recreational and therapeutic effects. The efficacy of medicinal cannabis for conditions such as epilepsy and pain has resulted in the discovery of the molecular targets of ... -
Structural Analysis of CavAb, a Prokaryotic Voltage-Gated Calcium Channel
Voltage-‐gated calcium channels are large membrane proteins that coordinate the movement of calcium into and out of the cell in response to changes in membrane potential, mediating signaling processes ... -
Structural and biochemical analysis of cullin-based ubiquitin ligases reveal regulatory mechanisms of ubiquitination machinery
(2006)Ubiquitin-dependent proteolysis controls protein stability and plays an important regulatory role in a broad spectrum of biological processes. At the core of the ubiquitination process are the ubiquitin ligases (UBL) that ... -
Structural basis for phosphatase regulation by the anchoring protein AKAP79
The calcium/calmodulin-activated protein phosphatase 2B (PP2B, or calcineurin) regulates diverse biological processes including glucose homeostasis and synaptic plasticity. PP2B is targeted to specific substrates, such as ... -
Structure and Function of the Mammalian Circadian Clock
Circadian clocks are essential in all kingdoms of life to maintain appropriate synchronization with their environment. Robust, 24-hr rhythms in eukaryotes are generated by a transcription-translation negative feedback loop. ... -
Structure study of a plant dual-affinity transceptor, CHL1
(2014-02-24)Nitrate is a key nutrient and signaling molecule for plant development and growth. It is the main source of inorganic nitrogen for plants grown in the aerobic soil condition. The growth of many species, including cultivated ... -
Targeted disruption of the RI and RII regulatory subunits of the cAMP-dependent protein kinase (PKA) in mice: physiological and neurobiological defects
(1996)The cAMP-dependent protein kinase (PKA) mediates the intracellular responses to myriad extracellular signals in eukaryotic organisms. Although the functions of this enzyme have been extensively studied, little is known ... -
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis
In the kidney, primary cilia projecting into the lumen of cells lining the inner medullary-collecting duct bend with urine flow to initiate intracellular signaling events. This mechano-sensory apparatus is defective in ... -
The Role of KLHDC2 in Recognizing Diglycine C-end Degron and its Therapeutic Potential
Ubiquitin-proteasome system is crucial for controlling essential cellular processes. Eukaryotic cells conjugate the eight kDa ubiquitin polypeptide to a variety of proteins to regulate their functions or turnover. Modification ...