Browsing Pharmacology by Title
Now showing items 77-82 of 82
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Ubiquitin-mediated Regulation of RNA Polymerase I in Saccharomyces cerevisiae
Ribosomes are key cellular components ensuring that cells correctly synthesize their protein cohort. Dysregulation of this process can lead to improper cell growth and is linked to the progression of several types of ... -
Ubx cofactors are required in San1-dependent nuclear protein quality control
Accumulation of misfolded proteins in the cell are linked to many human diseases. To ensure optimal cellular physiology, the cell has compartmentalized the protein quality control system (PQC). As a compartment, the nucleus ... -
Uncovering pathogenesis of the DNAJ-PKAc fusion in fibrolamellar carcinoma
Fibrolamellar carcinoma (FLC) is a rare liver cancer that occurs in healthy adolescents and young adults. FLCs uniquely produce DNAJ-PKAc, a de novo chimeric enzyme consisting of a chaperonin-binding domain fused to the ... -
Uncovering the Role of Protein Kinase TAOK2 as an Endoplasmic Reticulum-Microtubule Tether
Kinase signaling drives a multitude of components of neuronal development such as establishment of polarity, dendritic growth and arborization, dendritic spine formation, and synaptogenesis. Thousand And One amino acid ... -
Wnt/β-catenin Signaling Regulates Regeneration in Diverse Tissues of the Zebrafish
The ability to regenerate tissue after injury is limited by species, tissue type, and age of the organism. Understanding the mechanisms of endogenous regeneration provides greater insight into this remarkable biological ... -
WTX is a novel regulator of ubiquitination in the Wnt/beta-catenin and KEAP1/NRF2 pathways
(2012-08-10)Ubiquitination of proteins and subsequent proteosome-mediated degradation is one mechanism cells use to regulate protein steady-state levels. This essential process permits cells to rapidly respond to extracellular cues ...