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Theoretical and Numerical Studies of Dynamics in Nucleic Acids based on Experimental NMR Data
The collection of work presented in this thesis is directed towards building an understanding of the dynamics of nucleic acid molecules and their components using data obtained from solid state and solution NMR experiments. The focus of these studies is to develop analytical and numerical methods of elucidating motional ...
Measuring how lipid membranes respond to physical perturbations: How charge alters lipid miscibility, how shear disrupts interleaflet coupling, and how prebiotic compounds affect membrane stability
The physical and chemical properties of lipid bilayers determine their biological function as the main structural component of cell membranes. The response of lipid membranes to various perturbations is, in general, difficult to predict. This dissertation will discuss four sets of experiments to probe the behavior of lipid ...