Browsing Physiology and biophysics by Subject "arrhythmias; calcium; CaV1.2 channels; EC coupling; LQT8; Timothy syndrome"
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The role of coupled gating of L-type calcium channels in arrhythmogenesis in Timothy syndrome (LQT8)
(2012-09-10)L-type Ca<super>2+</super> (Ca<sub>V</sub>1.2) channels shape the cardiac action potential waveform and are essential for excitation-contraction (EC) coupling in the heart. We find that a transient subpopulation of 2 to ...