Browsing Public health genetics by Title
Now showing items 14-33 of 97
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CFTR F508del and population structure in a cystic fibrosis population
The Cystic Fibrosis Genome Project (CFGP) has assembled whole genome sequences on ~5K individuals with cystic fibrosis (CF) with the goal of identifying genetic modifiers of CF-related phenotypes. We hypothesized that the ... -
Characteristics of Male Partners Accessing Assisted Partner Services in Western Kenya
APS involves notifying and testing sexual or drug injecting partners of people living with HIV (PLHIV) also known as index participants. Using data from an implementation science study in Western Kenya, we aim to analyze ... -
Characterizing the Dynamics of the Type I Interferon Response in SARS-CoV-2 Infection to Identify ISGs that Serve as Possible Antiviral Restriction Factors
Previous work has implicated a dysregulated IFN signaling pathway in severe cases of COVID-19 and found that treatment of IFNs in severe patients can decrease viral load. Here, we characterize the response to type I ... -
Chromosomal karyotype abnormalities are associated with increased risk of hematologic malignancies
(2012-09-13)Chromosomal karyotype abnormalities provide clinical utility in the diagnosis and treatment of hematologic malignancies, and may be predictive of risk of malignant transformation in individuals without apparent clinical ... -
Clinical Sequencing at the UW Collagen Diagnostic Laboratory: An institutional experience with reimbursement and competing commercial services
Background: Next-generation sequencing (NGS) technologies pose unique challenges to traditional coverage and reimbursement mechanisms for clinical diagnostic testing. Despite rapid clinical implementation and growing test ... -
Comparing Genomic Data Sharing Policies from the National Institutes of Health, Global Alliance, and Reg4All: Common Ground and Future Directions
Genomic data sharing has become increasingly important with "big data" genomics. Successful genomic data sharing requires multiple stakeholders cooperating with one another. Using discourse analysis, I compared three ... -
Cost-utility analysis of EML4-ALK fusion testing followed by treatment with crizotinib in patients with Non-Small Cell Lung Cancer (NSCLC)
Objective NSCLC is the most common type of lung cancer and accounts for about 85% of all lung cancers. Currently a majority of patients with NSCLC are treated with surgical resection and/or cytotoxic drugs. Chemotherapy ... -
Dietary Magnesium, C-Reactive Protein and Interleukin-6: The Strong Heart Family Study
Background: Recent studies suggest that dietary factors, particularly magnesium (Mg) intake, influence systemic inflammation. Whether these associations are modified by genes associated with Mg metabolism and transport is ... -
Differential genome-wide DNA methylation in association with nightshift work: From discovery to policy
Shift work, working outside the hours of 6 a.m. to 6 p.m., is done by more than 21 million people in the United States and disproportionately done by the poor and by minorities. Many acute and chronic adverse health effects ... -
Disabling Pregnancy: Revealing how prenatal testing messages shape reproductive choices
Amniocentesis or chorionic villus sampling to diagnosis Down syndrome has long been an exemplar for prenatal genetic testing. With nearly 50 years of clinical application, the public has some awareness, knowledge, and ... -
Discussing race and genetics online: A qualitative interview study
Scientific racism maintains unjust racial hierarchies by portraying racial inequality as an inevitable result of innate differences between races. Proponents of modern scientific racism often cite geneticists’ ability to ... -
Dissecting Gene-Microbe-Exercise Interactions in Determining Host Phenotypes
Host genetics, gut microbiome, and physical activity are all important factors in determining human health. Clinical chemistries are commonly used in research and medicine to understand, diagnose, or treat disease. Previous ... -
DNA methylation changes associated with exposure to wildfire smoke in dogs enrolled in the Dog Aging Project
This study investigates the association between wildfire smoke and DNA methylation changes and how those changes may cause disease. We utilize data from the Precision Cohort in the Dog Aging Project which includes methylome ... -
The Effect of Gene-Obesity and Gene-Care Setting Interactions on Risk of Major Bleeding Events in Warfarin Users
A commonly prescribed anticoagulant, Warfarin (Coumadin®), reduces thromboembolic (blood clotting) event rates in patients with atrial fibrillation, stroke, joint replacement, and other conditions that present increased ... -
Employing Allostasis to Further Transdisciplinary Research
(2013-04-17)The intersection of biological and social science research is illuminating the causal relationships between societal stressors and chronic disease. The intersection of external pressures and internal responses provides a ... -
Establishing Initial Data and Assessing the Feasibility of a Community Collaborative to Improve Adherence to Essential Management in Beta-Thalassemia Patients in Pune, India
There are several large endogamous communities in the city of Pune, India that have a high prevalence of β-thalassemia major, which has led to local efforts to address the medical and psychosocial burden of the disease. ... -
Evaluating the "Sensitivity and Specificity" of the Newborn Screening Debate: How Tradeoffs between Population and Individual Benefit are shaping the Conversation between Public Health and Genetic Advocates
Newborn screening (NBS) is a national program that identifies and treats newborns with rare congenital conditions before the onset of symptoms, preventing premature death and serious disability in thousands of newborns ... -
An evaluation framework to assess educational genetic websites: Are they meeting public needs?
(2014-02-24)The current focus of genetic research on complex diseases will require more research participants to be recruited. Informed consent can be difficult to achieve in these settings so the public should have the opportunity ... -
Examining relationships between long non-coding RNA and warfarin pharmacogenes
Inter-individual variability in warfarin metabolism and response is influenced by multiple factors, including genetic variations in important pharmacogenes such as VKORC1 and CYP2C9. LncRNA (long non-coding RNA) plays roles ... -
Examining the Association Between an Endolysosomal Polygenic Risk Score and Alzheimer's Disease
Alzheimer’s disease (AD) is a highly heritable but polygenic common neurodegenerative disorder. Recent discoveries of AD risk susceptibility loci by genome-wide association studies (GWAS) have small overall effects, and ...