Browsing Public health genetics by Title
Now showing items 21-40 of 97
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Dietary Magnesium, C-Reactive Protein and Interleukin-6: The Strong Heart Family Study
Background: Recent studies suggest that dietary factors, particularly magnesium (Mg) intake, influence systemic inflammation. Whether these associations are modified by genes associated with Mg metabolism and transport is ... -
Differential genome-wide DNA methylation in association with nightshift work: From discovery to policy
Shift work, working outside the hours of 6 a.m. to 6 p.m., is done by more than 21 million people in the United States and disproportionately done by the poor and by minorities. Many acute and chronic adverse health effects ... -
Disabling Pregnancy: Revealing how prenatal testing messages shape reproductive choices
Amniocentesis or chorionic villus sampling to diagnosis Down syndrome has long been an exemplar for prenatal genetic testing. With nearly 50 years of clinical application, the public has some awareness, knowledge, and ... -
Discussing race and genetics online: A qualitative interview study
Scientific racism maintains unjust racial hierarchies by portraying racial inequality as an inevitable result of innate differences between races. Proponents of modern scientific racism often cite geneticists’ ability to ... -
Dissecting Gene-Microbe-Exercise Interactions in Determining Host Phenotypes
Host genetics, gut microbiome, and physical activity are all important factors in determining human health. Clinical chemistries are commonly used in research and medicine to understand, diagnose, or treat disease. Previous ... -
DNA methylation changes associated with exposure to wildfire smoke in dogs enrolled in the Dog Aging Project
This study investigates the association between wildfire smoke and DNA methylation changes and how those changes may cause disease. We utilize data from the Precision Cohort in the Dog Aging Project which includes methylome ... -
The Effect of Gene-Obesity and Gene-Care Setting Interactions on Risk of Major Bleeding Events in Warfarin Users
A commonly prescribed anticoagulant, Warfarin (Coumadin®), reduces thromboembolic (blood clotting) event rates in patients with atrial fibrillation, stroke, joint replacement, and other conditions that present increased ... -
Employing Allostasis to Further Transdisciplinary Research
(2013-04-17)The intersection of biological and social science research is illuminating the causal relationships between societal stressors and chronic disease. The intersection of external pressures and internal responses provides a ... -
Establishing Initial Data and Assessing the Feasibility of a Community Collaborative to Improve Adherence to Essential Management in Beta-Thalassemia Patients in Pune, India
There are several large endogamous communities in the city of Pune, India that have a high prevalence of β-thalassemia major, which has led to local efforts to address the medical and psychosocial burden of the disease. ... -
Evaluating the "Sensitivity and Specificity" of the Newborn Screening Debate: How Tradeoffs between Population and Individual Benefit are shaping the Conversation between Public Health and Genetic Advocates
Newborn screening (NBS) is a national program that identifies and treats newborns with rare congenital conditions before the onset of symptoms, preventing premature death and serious disability in thousands of newborns ... -
An evaluation framework to assess educational genetic websites: Are they meeting public needs?
(2014-02-24)The current focus of genetic research on complex diseases will require more research participants to be recruited. Informed consent can be difficult to achieve in these settings so the public should have the opportunity ... -
Examining relationships between long non-coding RNA and warfarin pharmacogenes
Inter-individual variability in warfarin metabolism and response is influenced by multiple factors, including genetic variations in important pharmacogenes such as VKORC1 and CYP2C9. LncRNA (long non-coding RNA) plays roles ... -
Examining the Association Between an Endolysosomal Polygenic Risk Score and Alzheimer's Disease
Alzheimer’s disease (AD) is a highly heritable but polygenic common neurodegenerative disorder. Recent discoveries of AD risk susceptibility loci by genome-wide association studies (GWAS) have small overall effects, and ... -
Exploring Strategies to Optimize the Value of Pharmacogenomic Testing
The emergence and continual advancement of genomic technologies offer numerous areas that warrant a critical appraisal for integrating new health care services to increase access and improve outcomes for patients. This ... -
Familial Aggregation of component traits of Metabolic Syndrome: The GENNID study
Introduction: Metabolic Syndrome (MetS) is defined as a constellation of cardiovascular and metabolic risk factors (elevated blood pressure, lower plasma HDL cholesterol, elevated plasma triglycerides [TG], higher blood ... -
Familial communication patterns in a cohort of men with metastatic prostate cancer: A cross-sectional exploratory analysis using data from the GENTleMEN Study
Background – A notable subset of men with metastatic prostate cancer (mPC) may carry an inherited germline mutation in a key cancer risk gene such as BRCA1 or BRCA2, predisposing them and their relatives who share the ... -
FcγRIIa and FcγRIIIa genetic polymorphisms and HIV-1 disease progression in Kenyan female sex workers
(2013-07-25)This study explores a potential correlation between genetic polymorphisms of the Fc gamma receptors IIa and IIIa and the rate of disease progression in HIV-infected female sex workers (FSW) from Kenya. Longitudinal data ... -
Fetal Alcohol Spectrum Disorder Primary Prevention through FASD Diagnosis: Identification of High-Risk Birth Mothers through the Diagnosis of their Children. Follow-up Study
Prenatal alcohol exposure is the leading known cause of preventable lifelong cognitive or behavioral disability. The spectrum of adverse outcomes observed among individuals with prenatal alcohol exposure is termed Fetal ... -
Findings of UTS for LS in an Integrated Healthcare System
Introduction: Lynch syndrome (LS) is associated with an increased risk of colorectal (CRC) and endometrial (EC) cancers. Universal tumor screening (UTS) of all patients diagnosed with CRC and EC is recommended to increase ... -
From Bench to Bedside: Understanding Multiple Dimensions of Pediatric HIV in Kenya
(2013-07-25)Introduction: Globally, over 3.3 million children are infected with HIV. Despite significant progress, there is a need to better understand mechanisms for transmission and progression of HIV in children. In addition, among ...