Browsing Public health genetics by Title
Now showing items 35-54 of 97
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Familial Aggregation of component traits of Metabolic Syndrome: The GENNID study
Introduction: Metabolic Syndrome (MetS) is defined as a constellation of cardiovascular and metabolic risk factors (elevated blood pressure, lower plasma HDL cholesterol, elevated plasma triglycerides [TG], higher blood ... -
Familial communication patterns in a cohort of men with metastatic prostate cancer: A cross-sectional exploratory analysis using data from the GENTleMEN Study
Background – A notable subset of men with metastatic prostate cancer (mPC) may carry an inherited germline mutation in a key cancer risk gene such as BRCA1 or BRCA2, predisposing them and their relatives who share the ... -
FcγRIIa and FcγRIIIa genetic polymorphisms and HIV-1 disease progression in Kenyan female sex workers
(2013-07-25)This study explores a potential correlation between genetic polymorphisms of the Fc gamma receptors IIa and IIIa and the rate of disease progression in HIV-infected female sex workers (FSW) from Kenya. Longitudinal data ... -
Fetal Alcohol Spectrum Disorder Primary Prevention through FASD Diagnosis: Identification of High-Risk Birth Mothers through the Diagnosis of their Children. Follow-up Study
Prenatal alcohol exposure is the leading known cause of preventable lifelong cognitive or behavioral disability. The spectrum of adverse outcomes observed among individuals with prenatal alcohol exposure is termed Fetal ... -
Findings of UTS for LS in an Integrated Healthcare System
Introduction: Lynch syndrome (LS) is associated with an increased risk of colorectal (CRC) and endometrial (EC) cancers. Universal tumor screening (UTS) of all patients diagnosed with CRC and EC is recommended to increase ... -
From Bench to Bedside: Understanding Multiple Dimensions of Pediatric HIV in Kenya
(2013-07-25)Introduction: Globally, over 3.3 million children are infected with HIV. Despite significant progress, there is a need to better understand mechanisms for transmission and progression of HIV in children. In addition, among ... -
Genetic and environmental associations with disease risk and drug response in Alaska Native people, and a responsive justice approach to reconciling statistical and ethical research demands.
Genetic research with diverse and underserved communities is important for expanding the benefits of genetic discoveries and their application to personalized medicine. In partnership with Alaska Native communities, we ... -
Genetic Numeracy in College Students: A quantitative analysis
(2012-08-10)Genetic Numeracy is a necessary component of decision making with genetic information. Quantitative studies of genetic numeracy are few in number. This thesis presents a preliminary analysis of a quantitative scale of ... -
Genetic risk factors associated with SARS-CoV-2 susceptibility in multiethnic populations
University of Washington Abstract Genetic risk factors associated with SARS-CoV-2 susceptibility in multiethnic populations Aditya Dandapani Sriram Chair of the Supervisory Committee:Kathleen Kerr Department of Biostatistics ... -
Genetic testing for Autism Spectrum Disorder (ASD): evaluating the challenges of genomic translation
Genetic testing for ASD is a new, complex and evolving aspect of healthcare, occurring in the setting of substantial challenges to the diagnosis and treatment of this group of conditions (Jeste & Geschwind, 2014). To date ... -
Genetic Testing in Immigration for Family Reunification: Ethical, Legal and Social Implications
(2013-02-25)This body of work addresses the ethical, legal and social implications of using genetic testing as part of US immigration procedures for family reunification. Last year, approximately two-thirds of immigrants who came to ... -
Genetic Variation in Circadian Genes and Survival in Patients with CRC
Disruption of circadian rhythm, characterized by sleep/activity pattern disturbances, is associated with an elevated risk of developing CRC as well as poor prognosis in patients with various cancers. To examine the ... -
Genetics and Infectious Diseases: From Host Transcriptome of HIV Infection to Bioethical Considerations in International Cohorts
Host genetic research has fueled infectious disease discoveries, including for HIV-1, from early candidate gene studies to recent multi-omics efforts. It offers opportunities for a more comprehensive understanding of ... -
Genomic sequence analysis of SARS-CoV-2 in the University of Washington community
Universities serve as unique communities in that students live in communal settings, attend social gatherings and travel during university holidays. We utilized genomic data from a university SARS-CoV-2 testing program ... -
Giving Vaccination a Shot: Describing seasonal influenza vaccine hesitancy at Public Health - Seattle & King County
Unlike healthcare workers, little research has been pursued to understand the reasons for declination of the seasonal influenza vaccine among clinical and non-clinical public health professionals. This research project ... -
Hereditary cancer screening attitudes and practices among primary care providers: A mixed-methods study
Purpose: Across the United States nationally recommended strategies for identifying asymptomatic individuals with predispositions to hereditary cancer syndromes are severely underutilized. The long term doctor-patient ... -
Illumination at the Intersections of Genomics and Public Health: A Study of Opsins, SPurS, Cluster Machine, and Ancestry in Genomics
Light is essential to life on planet Earth, yet researchers know very little about how biology and health are influenced by this ubiquitous source of energy. Opsins comprise a large and diverse group of light-sensitive ... -
Importance, Challenges, and Opportunities of Gene-Environment Interactions (GxE) Research: A Study of Parkinson's Disease
University of Washington Abstract Importance, Challenges, and Opportunities of Gene-Environment Interactions (GxE) Research: A Study of Parkinson's Disease Nirupama Nini Shridhar Chair of the Supervisory Committee Dr. Karen ... -
Inconclusive genetic test results for osteogenesis imperfecta in children with unexplained fractures - current practice and the provider perspective
<bold>Background:</bold> In children with unexplained fractures, healthcare providers often must consider whether the etiology is non-accidental injury (NAI) or an underlying predisposition to bone fractures, such as ... -
Information Sharing Patterns in a Population Genetic Screening Pilot Study
Population genetic screening for preventable adult-onset disease is an emerging public healthparadigm. There is limited information about the information sharing patterns of population screening participants. This thesis ...