Browsing Public health genetics by Title
Now showing items 15-34 of 47
-
Familial Aggregation of component traits of Metabolic Syndrome: The GENNID study
Introduction: Metabolic Syndrome (MetS) is defined as a constellation of cardiovascular and metabolic risk factors (elevated blood pressure, lower plasma HDL cholesterol, elevated plasma triglycerides [TG], higher blood ... -
FcγRIIa and FcγRIIIa genetic polymorphisms and HIV-1 disease progression in Kenyan female sex workers
(2013-07-25)This study explores a potential correlation between genetic polymorphisms of the Fc gamma receptors IIa and IIIa and the rate of disease progression in HIV-infected female sex workers (FSW) from Kenya. Longitudinal data ... -
Fetal Alcohol Spectrum Disorder Primary Prevention through FASD Diagnosis: Identification of High-Risk Birth Mothers through the Diagnosis of their Children. Follow-up Study
Prenatal alcohol exposure is the leading known cause of preventable lifelong cognitive or behavioral disability. The spectrum of adverse outcomes observed among individuals with prenatal alcohol exposure is termed Fetal ... -
From Bench to Bedside: Understanding Multiple Dimensions of Pediatric HIV in Kenya
(2013-07-25)Introduction: Globally, over 3.3 million children are infected with HIV. Despite significant progress, there is a need to better understand mechanisms for transmission and progression of HIV in children. In addition, among ... -
Genetic and environmental associations with disease risk and drug response in Alaska Native people, and a responsive justice approach to reconciling statistical and ethical research demands.
Genetic research with diverse and underserved communities is important for expanding the benefits of genetic discoveries and their application to personalized medicine. In partnership with Alaska Native communities, we ... -
Genetic Numeracy in College Students: A quantitative analysis
(2012-08-10)Genetic Numeracy is a necessary component of decision making with genetic information. Quantitative studies of genetic numeracy are few in number. This thesis presents a preliminary analysis of a quantitative scale of ... -
Genetic testing for Autism Spectrum Disorder (ASD): evaluating the challenges of genomic translation
Genetic testing for ASD is a new, complex and evolving aspect of healthcare, occurring in the setting of substantial challenges to the diagnosis and treatment of this group of conditions (Jeste & Geschwind, 2014). To date ... -
Genetic Testing in Immigration for Family Reunification: Ethical, Legal and Social Implications
(2013-02-25)This body of work addresses the ethical, legal and social implications of using genetic testing as part of US immigration procedures for family reunification. Last year, approximately two-thirds of immigrants who came to ... -
Giving Vaccination a Shot: Describing seasonal influenza vaccine hesitancy at Public Health - Seattle & King County
Unlike healthcare workers, little research has been pursued to understand the reasons for declination of the seasonal influenza vaccine among clinical and non-clinical public health professionals. This research project ... -
Illumination at the Intersections of Genomics and Public Health: A Study of Opsins, SPurS, Cluster Machine, and Ancestry in Genomics
Light is essential to life on planet Earth, yet researchers know very little about how biology and health are influenced by this ubiquitous source of energy. Opsins comprise a large and diverse group of light-sensitive ... -
Importance, Challenges, and Opportunities of Gene-Environment Interactions (GxE) Research: A Study of Parkinson's Disease
University of Washington Abstract Importance, Challenges, and Opportunities of Gene-Environment Interactions (GxE) Research: A Study of Parkinson's Disease Nirupama Nini Shridhar Chair of the Supervisory Committee Dr. Karen ... -
Inconclusive genetic test results for osteogenesis imperfecta in children with unexplained fractures - current practice and the provider perspective
<bold>Background:</bold> In children with unexplained fractures, healthcare providers often must consider whether the etiology is non-accidental injury (NAI) or an underlying predisposition to bone fractures, such as ... -
Large-Scale Genetic Analyses of Inflammatory Traits and Hematologic Parameters: Insights and Implications
Genome-wide association studies (GWAS) have identified thousands of trait-associated common variants, but for most complex traits these polymorphisms have explained only a small proportion of the phenotypic variation. In ... -
Latinos and genetics: Addressing the disparity of Latino research participation in genetics
Despite the growing presence of Latinos in the United States, research is falling short of proportionally representing Latinos among genetic research studies. Low rates of minorities engaging in biomedical research is an ... -
Mapping Metaphor: A qualitative analysis of metaphorical language in discussions of receiving exome and whole genome sequencing results
The rapid integration of genomics into clinical care, growing interest in offering genetic results to research participants, and consumer enthusiasm for personalized genomics requires greater understanding of how individuals ... -
Methods for reducing uncertainty in personalized medicine
(2014-02-24)<bold>Background.</bold> Evidence uncertainty and paternalistic practices in genomic medicine lead to suboptimal decision-making circumstances, and may result in unfavorable patient outcomes. Reducing decision uncertainty, ... -
Newborn Screening: Science, Policy, and People
(2013-02-25)University of Washington ABSTRACT Newborn Screening: Science, Policy, and People Catharine Riley Chair of the Supervisory Committee: Professor Carolyn Watts Health Services Background: Newborn screening (NBS) is a large-scale, ... -
Pharmacogenetic determinants of cyclophosphamide pharmacokinetics in pediatric cancer patients.
Purpose: Cyclophosphamide (CY) is an integral component of many combination chemotherapy regimens to treat pediatric cancer patients. Numerous metabolic and transport pathways are involved in the formation and elimination ... -
Pleiotropy: Epidemiologic analyses and implications for return of results
(2013-07-23)Pleiotropy refers to a single gene with multiple phenotypic effects. Genetic variants associated with multiple diseases can point to shared biologic mechanisms or other similarities. The first half of this dissertation ... -
The post-GWAS era: paving the way from association to functional insight
(2014-02-24)Considerable effort has been devoted to uncovering genetic variation that can be used to tailor prevention and treatment strategies for common diseases. Genome-wide association studies (GWAS) have proven to be an extremely ...