Browsing Public health genetics by Title
Now showing items 63-82 of 97
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Pharmacogenetic determinants of cyclophosphamide pharmacokinetics in pediatric cancer patients.
Purpose: Cyclophosphamide (CY) is an integral component of many combination chemotherapy regimens to treat pediatric cancer patients. Numerous metabolic and transport pathways are involved in the formation and elimination ... -
Physician Practices and Beliefs about Ovarian Cancer Screening in High-Risk Patients
Screening with transvaginal ultrasound and CA-125 is often recommended patients with pathogenic variants in the BRCA1 or BRCA2 genes despite evidence showing that screening does not result in mortality benefits. To better ... -
Pleiotropy: Epidemiologic analyses and implications for return of results
(2013-07-23)Pleiotropy refers to a single gene with multiple phenotypic effects. Genetic variants associated with multiple diseases can point to shared biologic mechanisms or other similarities. The first half of this dissertation ... -
Population Genetic Screening in Adults: Implementation and Health Equity Considerations
Population genetic screening among adults has been suggested as a strategy to identify people at risk for adult-onset diseases or disorders of cancer and high lipids who would benefit from early preventive intervention, ... -
Population-Wide Genomic Screening: Clinical Outcomes, Economic Value, and Ethics Considerations in Familial Hypercholesterolemia
Population-wide genomic screening is one of the great promises of precision medicine with opportunities to improve patient health outcomes, lower healthcare costs, and prevent disease. This dissertation examines population-wide ... -
The post-GWAS era: paving the way from association to functional insight
(2014-02-24)Considerable effort has been devoted to uncovering genetic variation that can be used to tailor prevention and treatment strategies for common diseases. Genome-wide association studies (GWAS) have proven to be an extremely ... -
Preimplantation genetic testing and perceptions of disability: A content analysis
Preimplantation genetic testing (PGT) is a technique used in tandem with in vitro fertilization (IVF) to identify embryos free of genetic conditions for later implantation. Hundreds of genetic conditions can be tested for ... -
Preparing for Personalized Medicine: Improving Genetic Screening Resources for Primary Care Providers
Due to the expansion of genetics testing and the current strain on the genetics services workforce, Primary Care Providers (PCPs) will have to play a growing role in the management of of patients with genetics needs. ... -
Previvors’ Perspectives on Population-Based Genetic Screening in the Primary Care Setting
Advances in next-generation sequencing have led to the utilization of multigene cancer panel testing for assessing inherent cancer risk. Multigene cancer panels could be the key to unlocking multiple clinical results at ... -
Relationship Between Motherhood Status, Motherhood Desire, and Psychological Outcome Measures in Previvors, Women with BRCA1 and BRCA2 Mutations
Previvors are women who have not yet had breast cancer but have a known BRCA1 or BRCA2 (BRCA will be used for both) mutation. Depression screening tools and cancer worry surveys are important markers of overall psychological ... -
Researcher Trustworthiness in Community-Academic Research Partnerships: Implications for Genomic Research
For many communities, health research exists on a backdrop of distrust of research institutions. Decades of harmful experiences across many types of health research have contributed, including studies of genetics, infectious ... -
Return of Aggregate Results in Biorepository Research: An Exploratory Study of Participant Perspectives and Preferences
(2013-04-17)This thesis reports a preliminary exploration of participant preferences and perspectives on the necessity for, and mode of, returning aggregate (or summary) results of genomic biorepository research. Fifteen semi-structured ... -
The Role of the HLA B and C Loci in Human Herpesvirus 8 Replication in a Ugandan Population
Kaposi sarcoma (KS) is one of the most common cancers among individuals with HIV, and the most common form of cancer in regions of Africa. Human herpesvirus 8 (HHV-8) is the etiologic factor in the development of KS; ... -
Sociodemographic and clinical correlates of immune activation in postpartum HIV-1/HSV-2 co-infected Kenyan women
University of Washington Abstract Sociodemographic and clinical correlates of immune activation in postpartum HIV-1/HSV-2 co-infected Kenyan women Anton N. Quist Chair of the Supervisory Committee: Professor Carey Farquhar ... -
Socioeconomic Status and Interest in Pursuing Genetic Testing for Hereditary Cancer in a US Based Population
Cancer is a significant burden to individuals and to the U.S. healthcare system (ACS, 2018).Individuals of low socioeconomic status (SES) have increased mortality and incidence of all types of cancers (Singh & Jemal, 2017). ... -
Statistical evaluation of forensic DNA sequence profiles
DNA evidence has revolutionized criminal investigations and has played a crucial role in thousands of forensic cases. Nowadays, DNA typing is a mature field and overwhelmingly seen as the gold standard in forensic science. ... -
The contribution of coding variants in cancer GWAS susceptibility regions to cancer risk
Deepening our understanding of the genetic architecture of cancer could provide insights into cancer biology to help mitigate the health effects of increasing global cancer incidence. Elucidating the shared genetic etiology ... -
The Genetics of Cardiovascular Disease: From Epidemiology to Clinical Practice
Chapter 1 contains a GWAS of QRS duration, a measure of ventricular depolarization and conduction, in 15,124 Hispanic/Latino individuals from four studies. We identified six loci associated with QRS (P<5x10-8), including ... -
The Importance of Environmental Embodiment for Public Health Professionals: Stress Triggers, Environmental Toxicants, and Strategies for Education
Human bodies exist as part of ecosystems and can be altered by environmental exposures. Environmental embodiment, the conceptual model described in this work, demonstrates how external exposures can shift body systems in ... -
The Return of Genetic Research Results in the Context of an International Colon Cancer Family Registry
The overall aim of this dissertation study was to describe the experience of the Colon Cancer Family Registry (C-CFR) with return of results (ROR) from genetic research and to document site-specific ROR outcomes. The C-CFR ...