Browsing Public health genetics by Title
Now showing items 76-95 of 97
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Sociodemographic and clinical correlates of immune activation in postpartum HIV-1/HSV-2 co-infected Kenyan women
University of Washington Abstract Sociodemographic and clinical correlates of immune activation in postpartum HIV-1/HSV-2 co-infected Kenyan women Anton N. Quist Chair of the Supervisory Committee: Professor Carey Farquhar ... -
Socioeconomic Status and Interest in Pursuing Genetic Testing for Hereditary Cancer in a US Based Population
Cancer is a significant burden to individuals and to the U.S. healthcare system (ACS, 2018).Individuals of low socioeconomic status (SES) have increased mortality and incidence of all types of cancers (Singh & Jemal, 2017). ... -
Statistical evaluation of forensic DNA sequence profiles
DNA evidence has revolutionized criminal investigations and has played a crucial role in thousands of forensic cases. Nowadays, DNA typing is a mature field and overwhelmingly seen as the gold standard in forensic science. ... -
The contribution of coding variants in cancer GWAS susceptibility regions to cancer risk
Deepening our understanding of the genetic architecture of cancer could provide insights into cancer biology to help mitigate the health effects of increasing global cancer incidence. Elucidating the shared genetic etiology ... -
The Genetics of Cardiovascular Disease: From Epidemiology to Clinical Practice
Chapter 1 contains a GWAS of QRS duration, a measure of ventricular depolarization and conduction, in 15,124 Hispanic/Latino individuals from four studies. We identified six loci associated with QRS (P<5x10-8), including ... -
The Importance of Environmental Embodiment for Public Health Professionals: Stress Triggers, Environmental Toxicants, and Strategies for Education
Human bodies exist as part of ecosystems and can be altered by environmental exposures. Environmental embodiment, the conceptual model described in this work, demonstrates how external exposures can shift body systems in ... -
The Return of Genetic Research Results in the Context of an International Colon Cancer Family Registry
The overall aim of this dissertation study was to describe the experience of the Colon Cancer Family Registry (C-CFR) with return of results (ROR) from genetic research and to document site-specific ROR outcomes. The C-CFR ... -
The Role of HPV E6 Oncoprotein as a Biomarker in Anal Cancer Screening in Persons Living with HIV
Early detection and prevention of anal cancer in high-risk groups such as persons living with HIV (PLWH) is of utmost importance. Most cases of anal cancer are caused by human papillomavirus (HPV), especially by HPV subtypes ... -
The Use of Y-Chromosome Profiles in Forensic Genetics
In forensic science, Y-STR testing is one of the most common tools used to interpret DNA typing results, specifically for human identification purposes (SWGDAM, 2014). With the complexity in DNA samples, not only can they ... -
The Y-Chromosome in Forensic and Public Health Genetics
Unlike the autosomes and X-chromosome, the Y-chromosome does not recombine with a homologous partner, save obligatory recombination with the X-chromosome in the pseudoautosomal regions. Because of the lack of recombination, ... -
Third-party interpretation of personal genetic data: the tools, users, and implications for policymaking
Individuals have unprecedented access to their “raw” or uninterpreted genetic data through direct-to-consumer (DTC) genetic testing, research participation, or clinical sequencing. Raw data can be transferred to a growing ... -
Toll-Like Receptor Polymorphism Associations with Trichomonas vaginalis infection among African couples: A Hypothesis-generating Study
Trichomonas vaginalis (Tv) is the most common non-viral, sexually transmitted infection. There is evidence that Tv infection increases risk of HIV-1 acquisition and transmission. The detailed mechanism underlying Tv infection ... -
Translational Research in Obstetric Pharmacology: Historical Trends, Prenatal Pharmacogenomics, and an Opportunistic Study of Placental ABCG2 and Fetal Glyburide Exposure
This dissertation is principally comprised of three distinct but related projects. The first is an assessment of the quantity and nature of obstetric pharmacology clinical trials conducted in the past decade, as well as a ... -
Trust and Consequences: Biorepositories, Health Learning Systems, and Beyond
Abstract: The functions and nature of trust have been widely explored within the context of biobanks. As an established body of literature demonstrates, trust is believed vital for conducting modern research in which ... -
Understanding and Managing Genomic Uncertainty
The overall aim of this dissertation was to study how patients understand and manage uncertainty in genomic medicine arising from Variants of Uncertain Significance, a type of genetic test result. Results from Chapter 2 ... -
Understanding of genetic test results for osteogenesis imperfecta by attorneys and child welfare workers in non-accidental injury cases
This dissertation research explored the ways in which child welfare workers and attorneys involved in non-accidental injury (NAI) cases understand and use genetic test results for osteogenesis imperfecta (OI). 14 semi-structured ... -
Universal Screening for Familial Colorectal Cancer Syndromes at Seattle Cancer Care Alliance: Qualitative Study of Providers involved in Implementation and Patients Experience with First Wave of Testing
Introduction: In 2013 the Seattle Cancer Care Alliance (SCCA) implemented universal screening procedures for people who present with colorectal cancer in order to help identify high risk families for which Lynch Syndrome ... -
Usability Testing and Understanding Genomic Uncertainty
Many cancers have a familial component that can be passed down to future generations and increase their risk of getting that cancer. Understanding one’s family history of cancer can help that individual take preventative ... -
User-Centered Design of Quality of Life Reports for Clinical Prostate Cancer Care
(2014-02-24)Background: Primary treatment of localized prostate cancer can result in bothersome urinary, sexual, and bowel symptoms. Yet clinical application of health-related quality of life (HRQOL) questionnaires is rare. We employed ... -
Validation of single nucleotide polymorphisms associated with acute kidney injury in bone marrow transplant recipients
(2013-07-25)Validation of single nucleotide polymorphisms associated with acute kidney injury in bone marrow transplant recipients Laurel K. Willig Timothy Thornton Background: Rates of acute kidney injury (AKI) as high as 75% have ...