Browsing Public health genetics by Title
Now showing items 1-20 of 97
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23andMe and the FDA: Negotiating Conceptions of Benefit in the Direct-to-Consumer Genetic Testing Regulatory Debate
The oversight and regulation of the direct-to-consumer (DTC) genetic testing industry has been a perennial topic of policy discussion since the emergence of the field in the early 2000s. Despite claiming authority to ... -
A Content Analysis of Stakeholder Interviews on Developing Pathways for Community-led Research with Big Data
In an era where Big Data (BD) informs nearly all aspects of human life, there are profound opportunities to translate BD research to guide physicians, epidemiologists, health policy experts, and community leaders in making ... -
A polygenic risk score-based analysis of gene-drug interactions in relation to type 2 diabetes risk.
Statin usage is associated with a higher risk of developing type 2 diabetes (T2D); however, statins have been shown to be safe and effective at lowering the risk of cardiovascular disease and are a widely used first line ... -
A TWAS-based investigation of gene expression mediated VTE risk
The corpus of GWAS has been successful in identifying many genetic loci associated with a large array of diseases, phenotypes, and other outcomes. However, the underlying molecular mechanisms behind such outcomes remain ... -
An Exploration of HLA Variants associated with Type-1 Diabetes Progression
The Diabetes Prevention Trial-1(DPT-1) assembled genome sequences on 711 participants with the goal of identifying HLA variants associated with Type 1 Diabetes(T1D) progression. We assessed HLA alleles and haplotypes across ... -
An Exploration of the Relationship Between Genetic Variants Associated with Alzheimer’s Disease and Measurements of Cognitive Processes Over Time
Late-onset Alzheimer’s Disease (LOAD) has been associated with more than twenty genetic susceptibility loci, to date. The present analysis builds on the work of the Alzheimer’s Disease Genetics Consortium (ADGC), the ... -
Antidepressant Use and Risk of Dementia and Cognitive Decline
The causes of late-onset dementia and cognitive decline are not fully understood, and are likely the result of a complex interplay between genetics, environment, and health and lifestyle factors. In light of the devastating ... -
Assessing Usability and User Attitudes about an Educational Website: ConnectMyVariant
Cascade testing for hereditary conditions such as cancer offers great potential for disease prevention, yet many challenges still exist for family communication and testing. ConnectMyVariant applies a unique combination ... -
Assessment of the Risk of Melanoma in Relatives of Patients with Parkinson's Disease
(2014-02-24)The goal of this pilot study was to describe the occurrence of melanoma among patients with PD in the Washington Parkinson's Disease Registry (WPDR), and their family members. Our evaluation has the following aims: 1) To ... -
An Association Analysis of Gene-Environment Interactions in the PON Region in Late-Onset Sporadic Parkinson's Disease
(2013-02-25)Abstract An Association Analysis of Gene-Environment Interactions in the PON Region in Late-Onset Sporadic Parkinson's Disease Nirupama Shridhar Chair of Supervisory Committee: Dr. Karen Edwards Institute for Public Health ... -
The association between common genetic variation in STK11 (LKB1) and colorectal adenomas in the Health Professional's Follow-up Study and the Nurses' Health Study
(2013-07-25)Germline mutations in serine-threonine kinase 11 (<ITALIC>STK11</ITALIC>) are hallmarks in hamartomatous polyps of the rare, hereditary disease, Peutz-Jeghers syndrome (PJS). PJS is associated with colorectal hamartomatous ... -
Beliefs and Values about gene therapy and gene editing in patients with hemophilia and their family members
Hemophilia is an inherited lifelong debilitating disease for which current treatment is non curative. Currently, the promise of gene therapy and gene editing as potential cures are undergoing research. However, we don’t ... -
Biological signatures of infectious disease resistance: Deciphering immunological mechanisms of resistance to tuberculosis (TB) by combining host genetics and immuno-transcriptomics
Understanding the biological signatures for resistance to Mycobacterium tuberculosis (Mtb) in a unique group termed resisters (RSTR) is crucial. Despite extensive exposure to the pathogen, these individuals remain uninfected, ... -
CFTR F508del and population structure in a cystic fibrosis population
The Cystic Fibrosis Genome Project (CFGP) has assembled whole genome sequences on ~5K individuals with cystic fibrosis (CF) with the goal of identifying genetic modifiers of CF-related phenotypes. We hypothesized that the ... -
Characteristics of Male Partners Accessing Assisted Partner Services in Western Kenya
APS involves notifying and testing sexual or drug injecting partners of people living with HIV (PLHIV) also known as index participants. Using data from an implementation science study in Western Kenya, we aim to analyze ... -
Characterizing the Dynamics of the Type I Interferon Response in SARS-CoV-2 Infection to Identify ISGs that Serve as Possible Antiviral Restriction Factors
Previous work has implicated a dysregulated IFN signaling pathway in severe cases of COVID-19 and found that treatment of IFNs in severe patients can decrease viral load. Here, we characterize the response to type I ... -
Chromosomal karyotype abnormalities are associated with increased risk of hematologic malignancies
(2012-09-13)Chromosomal karyotype abnormalities provide clinical utility in the diagnosis and treatment of hematologic malignancies, and may be predictive of risk of malignant transformation in individuals without apparent clinical ... -
Clinical Sequencing at the UW Collagen Diagnostic Laboratory: An institutional experience with reimbursement and competing commercial services
Background: Next-generation sequencing (NGS) technologies pose unique challenges to traditional coverage and reimbursement mechanisms for clinical diagnostic testing. Despite rapid clinical implementation and growing test ... -
Comparing Genomic Data Sharing Policies from the National Institutes of Health, Global Alliance, and Reg4All: Common Ground and Future Directions
Genomic data sharing has become increasingly important with "big data" genomics. Successful genomic data sharing requires multiple stakeholders cooperating with one another. Using discourse analysis, I compared three ... -
Cost-utility analysis of EML4-ALK fusion testing followed by treatment with crizotinib in patients with Non-Small Cell Lung Cancer (NSCLC)
Objective NSCLC is the most common type of lung cancer and accounts for about 85% of all lung cancers. Currently a majority of patients with NSCLC are treated with surgical resection and/or cytotoxic drugs. Chemotherapy ...