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Antidepressant Use and Risk of Dementia and Cognitive Decline
The causes of late-onset dementia and cognitive decline are not fully understood, and are likely the result of a complex interplay between genetics, environment, and health and lifestyle factors. In light of the devastating personal and economic burden of dementia, targeting midlife factors that contribute to these diseases ...
Examining the Association Between an Endolysosomal Polygenic Risk Score and Alzheimer's Disease
Alzheimer’s disease (AD) is a highly heritable but polygenic common neurodegenerative disorder. Recent discoveries of AD risk susceptibility loci by genome-wide association studies (GWAS) have small overall effects, and translation of these small effects into accurate personalized risk assessments is challenging. Pathway-specific ...