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Large-Scale Genetic Analyses of Inflammatory Traits and Hematologic Parameters: Insights and Implications
Genome-wide association studies (GWAS) have identified thousands of trait-associated common variants, but for most complex traits these polymorphisms have explained only a small proportion of the phenotypic variation. In an effort to assess the contribution of rare variation, sequencing based approaches targeting the exome ...
Chromosomal karyotype abnormalities are associated with increased risk of hematologic malignancies
Chromosomal karyotype abnormalities provide clinical utility in the diagnosis and treatment of hematologic malignancies, and may be predictive of risk of malignant transformation in individuals without apparent clinical presentation of a hematologic malignancy. To assess the association of large-scale chromosomal karyotype ...