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dc.contributor.authorLehar, Sophie Men_US
dc.date.accessioned2009-10-06T21:34:31Z
dc.date.available2009-10-06T21:34:31Z
dc.date.issued2005en_US
dc.identifier.otherb5647426xen_US
dc.identifier.other70783396en_US
dc.identifier.otherThesis 55503en_US
dc.identifier.urihttp://hdl.handle.net/1773/8356
dc.descriptionThesis (Ph. D.)--University of Washington, 2005.en_US
dc.description.abstractIn this study, I have attempted to understand how Notch signals promote different stages of T cell maturation by examining the regulation of Notch signals on two levels. First, I have used an in vitro culture system to examine how differential signals through 2 classes of Notch ligands, Jagged and Delta, influence thymocyte differentiation. These data reveal that Notch signals inhibit B cell development and promote the maturation of immature thymocytes in two separable stages. While both classes of Notch ligands are able to inhibit B cell development, only Delta is able to promote the proliferation of immature thymocytes. Second, I have examined how Deltex, an intracellular modulator of Notch signals, regulates Notch signals by generating mice that are deficient in two of the three known Deltex homologues. Although there is considerable evidence that over-expression of Deltex in hematopoietic stem cells can inhibit Notch signals, and that Deltex is highly expressed in developing thymocytes, my data reveals that expression of Deltex in T cell progenitors is not essential for regulating the early stages of T cell maturation.en_US
dc.format.extentvi, 101 p.en_US
dc.language.isoen_USen_US
dc.rightsCopyright is held by the individual authors.en_US
dc.rights.urien_US
dc.subject.otherTheses--Immunologyen_US
dc.titleTuning Notch signals in T cell developmenten_US
dc.typeThesisen_US


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