Hamerman, Jessica ABuechler, Matthew Bryan2014-10-132014-10-132014Buechler_washington_0250E_13717.pdfhttp://hdl.handle.net/1773/26104Thesis (Ph.D.)--University of Washington, 2014The roles of toll-like receptor and type I interferon signaling in modulating myeloid homeostasis are incompletely defined. Here, we investigate how these factors interact to influence myeloid development in the bone marrow and myeloid cell egress from the bone marrow. The findings described here advance our knowledge of basic immunology and may have clinical applications in the contexts of autoimmunity and infection.application/pdfen-USCopyright is held by the individual authors.Emergency Myelopoiesis; Myeloid Development; Plasmacytoid Dendritic Cell; Toll-like Receptor; Type I IFNImmunologyimmunologyThesis