Bremner, William J.Sheckter, Carol B.Matsumoto, Alvin M.Gross, Kenneth M.2008-10-172008-10-171990-11Am J Obstet Gynecol. 1990 Nov;163(5 Pt 2):1743-52http://hdl.handle.net/1773/4455Most men with hypogonadotropic eunuchoidism have absent luteinizing hormone and presumably absent luteinizing hormone-releasing hormone pulses. Pulsatile luteinizing hormone-releasing hormone therapy is effective in restoring normal gonadotropin secretion and testicular function and inducing fertility in men with hypogonadotropic eunuchoidism. Furthermore, pulsatile (versus continuous) luteinizing hormone-releasing stimulation of the pituitary gland is an absolute requirement for normal gonadotropin secretion. Men with idiopathic oligoazoospermia and selective elevation of follicle-stimulating hormone levels have slow luteinizing hormone and presumably luteinizing hormone-releasing pulse frequency. In these men, pulsatile luteinizing hormone--releasing treatment is effective in decreasing serum follicle-stimulating hormone levels, but it is unclear whether spermatogenesis and fertility are improved.en-USmale contraceptionandrology5-alpha reductase inhibitorstestosteronegonadotropinscolchicineklinefelter's syndromereifenstein's syndromespermatogenesisGonadorelin, administration & dosage, secretionFollicle Stimulating Hormone, blood, secretionInfertility, Male, etiologyMaleHumansResearch Support, U.S. Gov't, Non-P.H.S.Oligospermia, drug therapy, physiopathologyPregnancyTestosterone, bloodLuteinizing Hormone, blood, secretionEunuchism, drug therapy, physiopathologyFemaleComparative StudyRadioimmunoassayResearch Support, U.S. Gov't, P.H.S.Article