Samson, Jason2020-09-302020-09-306/5/2020Vol 1http://hdl.handle.net/1773/46248Bone tissue is the second most transplanted tissue each year. A demand for synthesized bone substitutes has led the development of materials that are biocompatible, bioactive, and bioabsorbable while also mechanically similar to bone tissue. Hydroxyapatite and calcium phosphate-based bioceramics have been the gold standard for substitute bone tissue development. Techniques have been developed such as formulation manipulation, freeze-drying, and 3D-printing gels that show promise in changing particle size and porosity. Higher porosity has been found to increase bioactivity, but also reduces compressive strength. Simple statistical methods and novel 3D-printing techniques have been shown to improve ultimate compressive strength and optimize scaffold formulas.CC BY-NC 4.0Tissue scaffoldHydroxyapatiteBone tissue engineeringBioceramicsBone tissue repairArticle