Taylor, R. JamesSiegel, Andrew F.Galitski, Timothy2009-12-152009-12-152007Taylor RJ, Siegel A, Galitski T. Network motif analysis of a multi-mode genetic-interaction network. Genome Biology. 2007;8(8):R160.10.1186/gb-2007-8-8-r160http://genomebiology.com/2007/8/8/R160http://hdl.handle.net/1773/15525Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in open-source software. Motifs extracted from multi-mode genetic-interaction networks form functional subnetworks, highlight genes dominating these subnetworks, and reveal genetic reflections of the underlying biochemical system.en-USCopyright Taylor et al.Article