2026-09-20T05:59:18Zhttps://digital.lib.washington.edu/server/oai/request

oai:digital.lib.washington.edu:1773/241782025-01-07T20:52:34Zcom_1773_4888col_1773_4895

Woodrow, Kim A Mahadevan, Reena 2013-11-14T20:54:35Z 2013-11-14T20:54:35Z 2013-11-14 2013 Mahadevan_washington_0250O_12370.pdf http://hdl.handle.net/1773/24178 Thesis (Master's)--University of Washington, 2013 Nanoparticles are emerging as versatile vehicles for drug delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated a wide variety of biological agents. However, PLGA nanoparticles are relatively inefficient at encapsulating small-molecule hydrophilic drugs. Liposomes encapsulate greater amounts of hydrophilic agents and demonstrate good cellular affinity; however, they lack controlled-release functionality. Hydrogel-core lipid-shell nanoparticles, or nanolipogels, combine the controlled-release capability of polymeric nanocarriers with the hydrophilic and cellular affinity of liposomes into a single drug delivery vehicle. This study establishes a facile, reproducible synthetic protocol for nanolipogels and evaluates hydrogel swelling as a mechanism for release of the small hydrophilic antiretroviral azidothymidine from nanolipogels. application/pdf en_US Copyright is held by the individual authors. Biomedical engineering bioengineering Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis Thesis No embargo open.access