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oai:digital.lib.washington.edu:1773/264682026-02-15T22:45:57Zcom_1773_4888col_1773_4918

Kaufman, Joel Miller, Carly Marie 2014-10-13T20:03:56Z 2014-10-13 2014 Miller_washington_0250O_13449.pdf http://hdl.handle.net/1773/26468 Thesis (Master's)--University of Washington, 2014 Background: Ambient air pollution has been linked to multiple adverse health outcomes. Most of these studies have use large-scale models to estimate air pollution exposures and have identified health outcomes based on hospital diagnosis codes. The Multi-Ethnic Study of Atherosclerosis (MESA) and MESA Air provide residence-level air pollution data. We investigated the association between these data and information collected prospectively on recent MESA participant infection. Methods & Results: MESA, a prospective cohort study, followed over 6800 participants with 5 study visits over 12 years. Data collected included participant self-report of recent respiratory infection. Individual ambient air pollution exposures to fine particulate matter (PM2.5), oxides of nitrogen (NOx and NO2), and black carbon (BC) were estimated. Cross-sectional and longitudinal associations were examined with generalized linear models for each pollutant adjusted for confounders: study site, season of exam, age, sex, race/ethnicity, smoking, and socio-economic status. Across all study sites, air pollution exposure estimates decreased. Report of recent respiratory infection was associated with season, the highest prevalence in winter. Nearly 18% of participants reported infection during the 2 weeks prior to their visit. Significant associations were seen between increased prevalence of infection and elevated exposures to PM2.5, NOx, and NO2. Discussion: In a large population-based cohort study, we found robust evidence that the prevalence of respiratory infection is increased in participants exposed to higher levels of ambient air pollution. application/pdf en_US Copyright is held by the individual authors. air pollution; infection; MESA Public health Environmental health epidemiology Association between Air Pollution Exposure and Self-Report of Recent Respiratory Infection: A MESA Air study Thesis Restrict to UW for 2 years -- then make Open Access 2016-10-02T20:03:56Z open.access