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oai:digital.lib.washington.edu:1773/527162026-02-16T02:55:31Zcom_1773_4888col_1773_4895

Ratner, Daniel M Limqueco, Elaine Sze 2025-01-23T20:05:00Z 2025-01-23 2024 Limqueco_washington_0250O_27806.pdf https://hdl.handle.net/1773/52716 Thesis (Master's)--University of Washington, 2024 Bioengineering drug delivery facilitates re-potentiation of existing drugs and drug candidates, bypassing hurdles in novel drug development and accelerating the advance of medicine. Drug delivery strategies aim to enhance therapeutic effect by enhancing delivery to the target cells or tissues, while curtailing adverse off-target effects. Existing approaches include liposomes, polymeric miscelle, protein-based nanoparticles, antibody-drug conjugates, dendrimers, and polymer drug conjugates. These systems provide the framework for the addition of additional functionalities, including modalities enabling targeting or controlled drug release. This thesis describes two projects utilizing the same RAFT-based polymerization strategy to synthesize polymer-drug conjugates, incorporating different modalities to enable glycan-based targeting to the Pseudomonas a. biofilm and to extend drug release within polymer-drug conjugate manufactured into nanofibers. application/pdf en_US CC BY Biofilm Carbohydrate Targeting Drug delivery Drugamer Nanofiber Polymer-Drug Conjugate Bioengineering Polymer chemistry Medicine Bioengineering Bioengineering functional polymer systems for glycan-based targeting and drug release Thesis Restrict to UW for 1 year -- then make Open Access 2026-01-23T20:05:00Z open.access