The structural dynamics of proteins are integral to protein function; if these structural dynamics are altered by mutation, the function of the protein can be altered as well, potentially resulting in disease. Experimental ...
Access to primary data and the provenance of derived data are increasingly recognized as an essential aspect of reproducibility in biomedical research. While productive data sharing has become the norm in some biomedical ...
Ontologies have become increasingly important for both representation of biomedical knowledge and for using that knowledge to facilitate data integration. However, ontologies are generally not presented in ways that are ...
Older adults, those 60 years and above, represent the quickest growing demographic group in the United States. Additionally, health related changes associated with aging make this population one of the primary consumers ...
Feature engineering, including input representation, feature design, evaluation, and optimization, is essential to success in machine learning. For unstructured data like images and texts, feature engineering can often ...
Actionable pharmacogenomic (PGx) information is growing exponentially with lowering costs of sequencing technologies, yet the best means to disseminate such data to physicians remains unclear. One method involves alerts ...
Proteins play critical roles in cellular processes. A protein's conformation directly relates to its biological function and, consequently, determination of such structure can provide great insight into a protein's function. ...
In low-resource settings, the prioritization of clinical care funding is often determined by immediate health priorities. As a result, investment directed towards the development of standards for clinical data representation ...
Every 25 seconds someone in the US has a cardiac event and one person per minute will die from it. ST-elevated myocardial infarction (STEMI), non ST-elevated myocardial infarction and unstable angina are caused by ischemia ...
Tracking tools that collect patient-generated data can have a major impact on health outcomes and patient-clinician communication. The relationship between the patient and the clinician can be fundamentally altered when ...
Use of a complete problem list can benefit patient care, quality improvement initiatives, and research activities. However, it can be time consuming for physicians to enter the correct encoded problem from a standardized ...
Studies of the genetic basis of complex disease present statistical and methodological challenges in the discovery of reliable and high-confidence genes that reveal biological phenomena underlying the etiology of disease ...
Cervical cancer is the second most frequent cancer in women around the world and affects half a million women per year. The World Health Organization (WHO) estimates that 275,000 women die every year, and 80% to 85% of ...
The real-time documentation of medications and procedures is an essential part of managing patient care during in-hospital "code blue" cardiac arrest emergencies. Care providers have voiced dissatisfaction with the existing ...
Despite implementation of electronic medical record (EMR) systems in the United States and other countries, EMRs often lack global access, standardization, an efficient interface, and effective knowledge-based tools at the ...
Synthetic biology is the emerging research and engineering field concerned with the design and construction of new biological functions and systems. Synthetic biologists are engineering organisms to solve outstanding ...
The increasing adoption of electronic medical records is producing a massive accumulation of routinelly collected electronic clinical data (ECD). This data can be used not only for direct patient care but for secondary ...
HIV is one of the biggest infectious killers worldwide. To prevent disease progression and avoid development of resistant strains to HIV, people living with HIV must adhere to complicated antiretroviral therapy (ART). Yet, ...
Clinical trial protocols are important documents that guide clinical research. Modern protocol development requires collective expertise from a group of Loosely-Coupled protocol writers, who work across distances and time ...