Testosterone delivery using glutamide-based complex high axial ratio microstructures

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dc.contributor.authorMatsumoto, Alvin M.en_US
dc.contributor.authorYager, Paulen_US
dc.contributor.authorAmory, John K.en_US
dc.contributor.authorGoldstein, Alex S.en_US
dc.contributor.authorVernon, Chrisen_US
dc.contributor.authorMartin, Stephanie M.en_US
dc.date.accessioned2008-10-17T20:43:22Z
dc.date.available2008-10-17T20:43:22Z
dc.date.issued2001-11en_US
dc.description.abstractComplex high axial ratio microstructures (CHARMs) were evaluated for delivery of testosterone in vivo. Methods to incorporate testosterone included noncovalent mixing and covalent attachment of testosterone to the lipid to form a prodrug monomer. When prepared by covalent attachment, testosterone-loaded CHARMs were resistant to in vitro spontaneous hydrolysis; when injected into rats, testosterone was released with biphasic kinetics consisting of a burst followed by a much slower phase. Some CHARM material associated with testosterone persisted at the site of injection for at least 9 days.en_US
dc.identifier.citationBioorg Med Chem. 2001 Nov;9(11):2819-25en_US
dc.identifier.urihttp://hdl.handle.net/1773/4470
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectmale contraceptionen_US
dc.subjectandrologyen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectcomplex high axial ratio microstructuresen_US
dc.subjectCHARMSen_US
dc.subjectgonadotropinsen_US
dc.subjecttestosteroneen_US
dc.subject.meshLipids, administration & dosage, chemistry, pharmacokineticsen_US
dc.subject.meshProdrugs, administration & dosage, pharmacokineticsen_US
dc.subject.meshRatsen_US
dc.subject.meshTestosterone, administration & dosage, blood, pharmacokineticsen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshDelayed-Action Preparationsen_US
dc.subject.meshSurface-Active Agents, administration & dosage, chemistry, pharmacokineticsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshGlutamine, analogs & derivatives, chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshInjectionsen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.titleTestosterone delivery using glutamide-based complex high axial ratio microstructuresen_US
dc.typeArticleen_US

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