Anti-Markovnikov Hydroarylation of Alkenes with Aryl Halides and Synthesis and Characterization of a Monomeric Copper Hydride complex

Abstract

Chapter 1 describes the nickel-catalyzed hydroarylation of alkenes. This reaction involves reductive cross coupling of alkenes and aryl halides in the presence of a silane as the hydride donor. High anti-Markovnikov selectivity is achieved in this reaction, and broad functional group compatibility demonstrates its utility, coupling a wide range of alkene substrates, such as alkyl- and aryl-substituted alkenes as well as enol ethers and diene. Chapter 2 describes efforts to synthesize monomeric copper hydride complexes. Preparation and characterization of various copper complexes using tris(pyrazolyl)borate (Tp), methane (Tpm), - ethane (Tpe) and N-heterocyclic carbene (NHC) ligands were performed. Reaction of Tp ligated copper (II) methoxide complex with silane showed evidence of the existence of copper (II) hydride in the reaction.