Examining relationships between long non-coding RNA and warfarin pharmacogenes

Abstract

Inter-individual variability in warfarin metabolism and response is influenced by multiple factors, including genetic variations in important pharmacogenes such as VKORC1 and CYP2C9. LncRNA (long non-coding RNA) plays roles in diverse cellular processes including gene regulation. This study explored the relationship between the hepatic expression of lncRNA genes and warfarin pharmacogenes through correlation analysis and penalized linear regression modeling. Significant correlations emerged between specific lncRNA genes and warfarin pharmacogenes. The Lasso penalized linear regression model also highlighted the lncRNA genes impacting the variability in warfarin pharmacogene expression. Despite study limitations, these novel results provide a basis for further exploration of these relationships and their underlying biological mechanisms. Understanding these connections could potentially lead to improved warfarin dosing for patients on the medication, enhancing both patient safety and drug efficacy. Integrating pharmacogenomics and lncRNA research holds promise for refining drug dosing strategies and advancing personalized medicine.