Risk factors and the association of multiple HPV infections on pre-invasive cervical lesions and invasive cervical cancers among women with HPV infection in Senegal, West Africa

Abstract

Infection with multiple HPV types may increase or reduce the risk of pre-invasive cervical lesions and invasive cervical cancers. We conducted a secondary analysis of data to assess the risk factors of infection with multiple HPV types, and the association of infection with multiple HPV types and pre-invasive cervical lesions and invasive cancers among 1202 women who tested positive for HPV serology in 3 clinics in Senegal. We used Poisson regression analysis with robust standard error to calculate risk estimates and 95% CI. We did not find any significant association between different socio-demographic characteristics and behavioral factors associated with infection with multiple HPV types. We also did not find any significant association of infection with multiple HPV types and pre-invasive cervical lesions and invasive cervical cancers. We did, however, find a positive trend towards multiple HPV infection in pre-invasive cervical lesions and a negative trend in invasive cervical cancers.