Sterol-phospholipid interactions in model lipid membranes

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dc.contributor.advisorKeller, Sarah L
dc.contributor.authorLitz, Jonathan Paul
dc.date.accessioned2016-03-11T22:38:26Z
dc.date.issued2016-03-11
dc.date.submitted2015-12
dc.descriptionThesis (Ph.D.)--University of Washington, 2015-12
dc.description.abstractCell membranes feature complex intermolecular interactions between phospholipids and sterols. In this dissertation, I discuss how the accessibility (a measure of chemical activity) of cholesterol in a lipid bilayer varies as a function of bilayer composition. By using the two complementary cyclodextrins (methyl-beta and hydroxypropyl-alpha), I assay the accessibility of both cholesterol and phospholipids for removal from lipid bilayers. Next, I present ternary phase diagrams of mixtures of an unsaturated lipid, a saturated lipid, and one of three different sterols (β-sitosterol, stigmasterol, and ergosterol). Finally, I present research to which I contributed on the thickness mismatch of coexisting liquid phases in model lipid membranes.
dc.embargo.lift2017-03-11T22:38:26Z
dc.embargo.termsRestrict to UW for 1 year -- then make Open Access
dc.format.mimetypeapplication/pdf
dc.identifier.otherLitz_washington_0250E_15264.pdf
dc.identifier.urihttp://hdl.handle.net/1773/35153
dc.language.isoen_US
dc.subjectchemical kinetics; cholesterol; cyclodextrin; fluorescence microscopy; lipids; membrane biophysics
dc.subject.otherChemistry
dc.subject.otherBiophysics
dc.subject.otherPhysical chemistry
dc.subject.otherchemistry
dc.titleSterol-phospholipid interactions in model lipid membranes
dc.typeThesis

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