The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management
| dc.contributor.author | Bremner, William J. | en_US |
| dc.contributor.author | Sheckter, Carol B. | en_US |
| dc.contributor.author | Matsumoto, Alvin M. | en_US |
| dc.contributor.author | Gross, Kenneth M. | en_US |
| dc.date.accessioned | 2008-10-17T20:43:03Z | |
| dc.date.available | 2008-10-17T20:43:03Z | |
| dc.date.issued | 1990-11 | en_US |
| dc.description.abstract | Most men with hypogonadotropic eunuchoidism have absent luteinizing hormone and presumably absent luteinizing hormone-releasing hormone pulses. Pulsatile luteinizing hormone-releasing hormone therapy is effective in restoring normal gonadotropin secretion and testicular function and inducing fertility in men with hypogonadotropic eunuchoidism. Furthermore, pulsatile (versus continuous) luteinizing hormone-releasing stimulation of the pituitary gland is an absolute requirement for normal gonadotropin secretion. Men with idiopathic oligoazoospermia and selective elevation of follicle-stimulating hormone levels have slow luteinizing hormone and presumably luteinizing hormone-releasing pulse frequency. In these men, pulsatile luteinizing hormone--releasing treatment is effective in decreasing serum follicle-stimulating hormone levels, but it is unclear whether spermatogenesis and fertility are improved. | en_US |
| dc.identifier.citation | Am J Obstet Gynecol. 1990 Nov;163(5 Pt 2):1743-52 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1773/4455 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | male contraception | en_US |
| dc.subject | andrology | en_US |
| dc.subject | 5-alpha reductase inhibitors | en_US |
| dc.subject | testosterone | en_US |
| dc.subject | gonadotropins | en_US |
| dc.subject | colchicine | en_US |
| dc.subject | klinefelter's syndrome | en_US |
| dc.subject | reifenstein's syndrome | en_US |
| dc.subject | spermatogenesis | en_US |
| dc.subject.mesh | Gonadorelin, administration & dosage, secretion | en_US |
| dc.subject.mesh | Follicle Stimulating Hormone, blood, secretion | en_US |
| dc.subject.mesh | Infertility, Male, etiology | en_US |
| dc.subject.mesh | Male | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Research Support, U.S. Gov't, Non-P.H.S. | en_US |
| dc.subject.mesh | Oligospermia, drug therapy, physiopathology | en_US |
| dc.subject.mesh | Pregnancy | en_US |
| dc.subject.mesh | Testosterone, blood | en_US |
| dc.subject.mesh | Luteinizing Hormone, blood, secretion | en_US |
| dc.subject.mesh | Eunuchism, drug therapy, physiopathology | en_US |
| dc.subject.mesh | Female | en_US |
| dc.subject.mesh | Comparative Study | en_US |
| dc.subject.mesh | Radioimmunoassay | en_US |
| dc.subject.mesh | Research Support, U.S. Gov't, P.H.S. | en_US |
| dc.title | The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management | en_US |
| dc.type | Article | en_US |