Palladium-Catalyzed Cross-Couplings of 2-Alkylaziridines and Alkenylboronic Acids

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dc.contributor.advisorMichael, Forrest E
dc.contributor.authorLesniak, Valerie Ann
dc.date.accessioned2016-09-22T15:43:40Z
dc.date.available2016-09-22T15:43:40Z
dc.date.issued2016-09-22
dc.date.submitted2016-08
dc.descriptionThesis (Master's)--University of Washington, 2016-08
dc.description.abstractA new method to synthesize substituted homoallylic amines is reported. Homoallylic amines are important structural moieties in natural products and pharmaceutical agents. The reaction couples N-nosyl-2-alkylaziridines with alkenylboronic acids under palladium catalysis. This work examines the role of base and proton donor additive in facilitating formation of the desired product. The reaction has promising yields and appears to have a wide substrate scope. This work expands upon the Michael lab's previous work with cross-couplings of alkyl aziridines and arylboronic acids.
dc.embargo.termsOpen Access
dc.format.mimetypeapplication/pdf
dc.identifier.otherLesniak_washington_0250O_15843.pdf
dc.identifier.urihttp://hdl.handle.net/1773/37060
dc.language.isoen_US
dc.subjectalkenylboronic acid
dc.subjectaziridine
dc.subjectboronic acid
dc.subjectcross-coupling
dc.subjecthomoallylic amine
dc.subjectPalladium-catalyzed
dc.subject.otherChemistry
dc.subject.otherOrganic chemistry
dc.subject.otherchemistry
dc.titlePalladium-Catalyzed Cross-Couplings of 2-Alkylaziridines and Alkenylboronic Acids
dc.typeThesis

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