Depot-medroxyprogesterone acetate use and the concentration of Gardnerella vaginalis in vaginal secretions: A cross-sectional study

Abstract

Studies have observed an association between depot-medroxyprogesterone acetate (DMPA) use and bacterial vaginosis (BV). This well-powered cross-sectional study found no association between DMPA use and vaginal fluid concentrations of Gardnerella vaginalis or measures of bacterial community diversity. Further research is needed to identify microbial mechanisms linking DMPA and BV.