Testosterone delivery using glutamide-based complex high axial ratio microstructures
Date
2001-11Author
Matsumoto, Alvin M.
Yager, Paul
Amory, John K.
Goldstein, Alex S.
Vernon, Chris
Martin, Stephanie M.
Metadata
Show full item recordAbstract
Complex high axial ratio microstructures (CHARMs) were evaluated for
delivery of testosterone in vivo. Methods to incorporate testosterone
included noncovalent mixing and covalent attachment of testosterone to the
lipid to form a prodrug monomer. When prepared by covalent attachment,
testosterone-loaded CHARMs were resistant to in vitro spontaneous
hydrolysis; when injected into rats, testosterone was released with
biphasic kinetics consisting of a burst followed by a much slower phase.
Some CHARM material associated with testosterone persisted at the site of
injection for at least 9 days.