Exploring potential risk factors for the asymptomatic intestinal carriage of ciprofloxacin-resistant uropathogenic Escherichia coli

Abstract

This retrospective cohort study analyzed data collected under a larger parent study, the CLUE study in the Sokurenko laboratory at the University of Washington, to explore risk factors for the asymptomatic intestinal carriage of ciprofloxacin-resistant Escherichia coli (E.coli) (CipRE). This study included 1719 women aged 50 and older within the Kaiser Permanente Washington health system. Odds ratios (OR) and confidence intervals (CIs) from unadjusted and age-adjusted logistic regression models were used to explore the relationship between CipRE carriage and mood disorders, metabolic conditions and gastrointestinal conditions. Metabolic conditions were associated with CipRE carriage in the unadjusted (OR 1.42, 95% CI 1.07-1.89) and adjusted (OR 1.42, 95% CI 1.05-1.92) model. Gastrointestinal conditions were also associated with CipRE carriage in the unadjusted (OR 1.48, 95% CI 1.05-2.06) and adjusted (OR 1.47, 95% CI 1.04-2.06) model. Metabolic conditions were associated with two virulent CipRE sequence types, ST131-H30 and ST1193, in the unadjusted (OR 1.51, 95% CI 1.04-2.22) and adjusted (OR 1.50, 95% CI 1.01-2.26) model.