Exploring potential risk factors for the asymptomatic intestinal carriage of ciprofloxacin-resistant uropathogenic Escherichia coli

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dc.contributor.advisorFishman, Paul A
dc.contributor.authorBowers, Victoria Marie
dc.date.accessioned2022-07-14T22:03:08Z
dc.date.available2022-07-14T22:03:08Z
dc.date.issued2022-07-14
dc.date.submitted2022
dc.descriptionThesis (Master's)--University of Washington, 2022
dc.description.abstractThis retrospective cohort study analyzed data collected under a larger parent study, the CLUE study in the Sokurenko laboratory at the University of Washington, to explore risk factors for the asymptomatic intestinal carriage of ciprofloxacin-resistant Escherichia coli (E.coli) (CipRE). This study included 1719 women aged 50 and older within the Kaiser Permanente Washington health system. Odds ratios (OR) and confidence intervals (CIs) from unadjusted and age-adjusted logistic regression models were used to explore the relationship between CipRE carriage and mood disorders, metabolic conditions and gastrointestinal conditions. Metabolic conditions were associated with CipRE carriage in the unadjusted (OR 1.42, 95% CI 1.07-1.89) and adjusted (OR 1.42, 95% CI 1.05-1.92) model. Gastrointestinal conditions were also associated with CipRE carriage in the unadjusted (OR 1.48, 95% CI 1.05-2.06) and adjusted (OR 1.47, 95% CI 1.04-2.06) model. Metabolic conditions were associated with two virulent CipRE sequence types, ST131-H30 and ST1193, in the unadjusted (OR 1.51, 95% CI 1.04-2.22) and adjusted (OR 1.50, 95% CI 1.01-2.26) model.
dc.embargo.termsOpen Access
dc.format.mimetypeapplication/pdf
dc.identifier.otherBowers_washington_0250O_24462.pdf
dc.identifier.urihttp://hdl.handle.net/1773/48721
dc.language.isoen_US
dc.relation.haspartSupp Table 1. Literature review Diagnoses and prescriptions associated with gut dysbiosis.xlsx; spreadsheet; Literature review Diagnoses and prescriptions associated with gut dysbiosis.
dc.relation.haspartSupp Table 2. Prescriptions and diagnoses included within each clinical status group.xlsx; spreadsheet; Prescriptions and diagnoses included within each clinical status group.
dc.rightsCC BY-NC
dc.subjectAntibiotic resistance
dc.subjectAntimicrobial resistance
dc.subjectAsymptomatic carriage
dc.subjectCystitis
dc.subjectEscherichia coli
dc.subjectUrinary tract infection
dc.subjectPublic health
dc.subject.otherHealth services
dc.titleExploring potential risk factors for the asymptomatic intestinal carriage of ciprofloxacin-resistant uropathogenic Escherichia coli
dc.typeThesis

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