Protein-bound uremic toxin kinetics modeling for a new dialysis device

Abstract

Addition to the conventional hemodialysis, a protein-bound uremic toxins process device is designed. To better understand the mechanism of this novel device, we build a fixed-bed adsorbent column model to simulate this process. Also, we build a compatible hemodialysis model with Python language. This hemodialysis model consists of a three-compartment patient model, a dialyzer model and toxin removal unit models where the PBUTs adsorption model can be plugged in. With these models, the effect of various parameters affecting adsorption process are discussed in detail.